Sommer H, Harrer G
Psychiatrische Fachpraxis, Universität Salzburg, Austria.
J Geriatr Psychiatry Neurol. 1994 Oct;7 Suppl 1:S9-11. doi: 10.1177/089198879400700104.
One hundred and five outpatients with mild depressions of short duration were treated in a double-blind study with either 3 x 300 mg hypericum extract or placebo. The therapy phase was 4 weeks. The effectiveness was judged according to the Hamilton Depression Scale after 2 and 4 weeks. The values of the mean basic score in these periods fell from 15.8 to 9.6 or 7.2 in the active group, and in the placebo group, from 15.8 to 12.3 and 11.3. The differences between active and placebo groups were statistically significant with P < .05 and P < .01 achieved after 2 and 4 weeks, respectively. In the active group, 28 of 42 patients (67%) and, in the placebo group, 13 of 47 patients (28%) responded to treatment. Notable side effects were not found.
105例病程较短的轻度抑郁症门诊患者参与了一项双盲研究，他们被随机分为两组，分别服用3次每次300毫克的金丝桃提取物或安慰剂。治疗阶段为4周。在2周和4周后，根据汉密尔顿抑郁量表来判断疗效。在这些时间段内，治疗组的平均基础评分从15.8降至9.6或7.2，而安慰剂组则从15.8降至12.3和11.3。治疗组和安慰剂组之间的差异具有统计学意义，分别在2周和4周后P值小于0.05和P值小于0.01。治疗组中，42例患者中有28例（67%）对治疗有反应，安慰剂组中，47例患者中有13例（28%）对治疗有反应。未发现明显的副作用。
