Harrer G, Hübner W D, Podzuweit H
Institut für Forensische Psychiatrie, Universität Salzburg, Austria.
J Geriatr Psychiatry Neurol. 1994 Oct;7 Suppl 1:S24-8. doi: 10.1177/089198879400700108.
A randomized, double-blind study examining the effectiveness and tolerance of a standardized hypericum preparation when compared to maprotiline was performed in a group of 102 patients with depression, in accordance with ICD-10, F 32.1. The study was conducted in the offices of neurology and psychiatry specialists. The patients received, over a period of 4 weeks, either 3 x 300 mg of the hypericum extract or 3 x 25 mg maprotiline pills of identical appearance. Effectiveness was determined using the Hamilton Depression Scale (HAMD), the Depression Scale according to von Zerssen (D-S), and the Clinical Global Impression Scale (CGI). The total score of the HAMD scale dropped during the 4 weeks of therapy in both treatment groups by about 50%. The mean values of the D-S scale and the CGI scale showed similar results, and after 4 weeks of therapy, no significant differences in either treatment group were noticed. The onset of the effects occurred up to the second week of treatment, but were observed earlier with maprotiline than with the hypericum extract. On the other hand, maprotiline treatment resulted in more cases of tiredness, mouth dryness, and heart complaints.
一项针对102名符合ICD - 10，F 32.1标准的抑郁症患者进行的随机双盲研究，对比了一种标准化金丝桃制剂与马普替林的有效性和耐受性。该研究在神经科和精神科专家的诊所进行。患者在4周时间内，分别服用3次、每次300毫克的金丝桃提取物，或3次、每次25毫克外观相同的马普替林药丸。使用汉密尔顿抑郁量表（HAMD）、冯·泽尔森抑郁量表（D - S）和临床总体印象量表（CGI）来确定有效性。在两个治疗组中，HAMD量表的总分在4周治疗期间均下降了约50%。D - S量表和CGI量表的平均值显示出相似的结果，且在4周治疗后，两个治疗组均未发现显著差异。治疗效果在治疗的第二周出现，但马普替林比金丝桃提取物更早观察到效果。另一方面，马普替林治疗导致更多的疲劳、口干和心脏不适病例。
