Hänsgen K D, Vesper J, Ploch M
Institut für Psychologie, Universität Fribourg/Schweiz, Germany.
J Geriatr Psychiatry Neurol. 1994 Oct;7 Suppl 1:S15-8. doi: 10.1177/089198879400700106.
Seventy-two depressive patients of 11 physicians' practices were treated in a double-blind study for a period of 6 weeks either with hypericum extract LI 160 or with placebo. Inclusion criterion was a major depression in accordance with DSM-III-R. The changes were assessed using four psychometric scales (HAMD, D-S, BEB, CGI). After 4 weeks of therapy, the statistical evaluation revealed a significant improvement in all four psychometric tests in the active group as compared to the placebo group. After switching the placebo group to active treatment (5th to 6th week of therapy), significant improvements were found in the original placebo group. No serious side effects were observed.
在一项双盲研究中，11位医生诊所的72名抑郁症患者接受了为期6周的治疗，分别服用金丝桃提取物LI 160或安慰剂。纳入标准为符合《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）的重度抑郁症。使用四种心理测量量表（汉密尔顿抑郁量表、抑郁自评量表、简明精神病评定量表、临床总体印象量表）评估变化情况。治疗4周后，统计评估显示，与安慰剂组相比，治疗组的所有四项心理测量测试均有显著改善。在将安慰剂组改为活性治疗后（治疗第5至6周），原安慰剂组也有显著改善。未观察到严重副作用。
