Hübner W D, Lande S, Podzuweit H
Lichtwer Pharma GmbH, Berlin, Germany.
J Geriatr Psychiatry Neurol. 1994 Oct;7 Suppl 1:S12-4. doi: 10.1177/089198879400700105.
In a randomized, placebo-controlled, double-blind study, 39 patients with depression with somatic symptoms were treated with hypericum extract LI 160. The therapy lasted for 4 weeks; the dosage was 300 mg three times daily. At the onset of the study as well as after 2 and 4 weeks, the following criteria were analyzed: HAMD, B-L, CGI, and vegetative symptoms. The results show a significant improvement in the active treatment group at the 5% level as compared to placebo. Seventy percent of the patients treated with LI 160 were free of symptoms after 4 weeks. Typical symptoms of the depression such as lack of activity, tiredness, fatigue, and disturbed sleep, were especially responsive. In no case were any undesirable side effects observed.
在一项随机、安慰剂对照、双盲研究中，39例伴有躯体症状的抑郁症患者接受金丝桃提取物LI 160治疗。治疗持续4周；剂量为每日3次，每次300毫克。在研究开始时以及2周和4周后，分析了以下标准：汉密尔顿抑郁量表（HAMD）、B-L、临床总体印象量表（CGI）和躯体症状。结果显示，与安慰剂相比，活性治疗组在5%的水平上有显著改善。接受LI 160治疗的患者中有70%在4周后无症状。抑郁症的典型症状，如活动缺乏、疲倦、乏力和睡眠障碍，反应尤为明显。未观察到任何不良副作用。
