Francaviglia N, Silvestro C, Maiello M, Bragazzi R, Bernucci C
Department of Neurosurgery, University of Genoa Medical School, Italy.
Br J Neurosurg. 1994;8(5):567-71. doi: 10.3109/02688699409002949.
Progressive Systemic Scleroderma (PSS) is a generalized disease of connective tissue involving the skin, as well as other internal organs. The cutaneous signs are characterized by a progressive sclerosis and loss of function or dexterity in the hands. Between 1987 and 1992, 15 patients affected by scleroderma were treated by means of spinal cord stimulation (SCS) in order to reduce signs and symptoms related to vascular damage. The follow-up ranged from 12 months to 6 years. The study confirms that SCS is an effective therapy in patients with PSS and Raynaud's phenomenon because of its beneficial effects on the Raynaud episodes, ulcers, pain, vascular sclerosis and hand function. This method may have a primary role in the treatment of this chronic disorder because of the high probability of failure of other medical or surgical therapy.
进行性系统性硬化症(PSS)是一种累及皮肤以及其他内脏器官的全身性结缔组织疾病。皮肤症状的特征是手部进行性硬化以及功能或灵活性丧失。1987年至1992年间,15名硬皮病患者接受了脊髓刺激(SCS)治疗,以减轻与血管损伤相关的体征和症状。随访时间为12个月至6年。该研究证实,SCS对患有PSS和雷诺现象的患者是一种有效的治疗方法,因为它对雷诺发作、溃疡、疼痛、血管硬化和手部功能具有有益作用。由于其他药物或手术治疗失败的可能性很高,这种方法可能在这种慢性疾病的治疗中起主要作用。