McGregor I A
Bull World Health Organ. 1974;50(3-4):259-66.
This paper considers the participation of macrophages, thymus-dependent lymphocytes (T-cells), and thymus-independent lymphocytes (B-cells) in man's immune response to malaria. Although phagocytosis by macrophages is an important feature of malaria the full extent of cooperation between these cells and T- and B-cells is not known. Evidence that T-cells play an important defensive role is at present unconvincing. B-cells on the other hand function importantly in the synthesis of immunoglobulins and specific antibodies and factors possibly influencing their activity are considered. Different epidemiological patterns of malaria antibodies in sera are described and the need for the routine inclusion of reliable antibody detection tests as part of malaria survey techniques, particularly where antimalarial drug usage is frequent, is emphasized.
本文探讨了巨噬细胞、胸腺依赖性淋巴细胞（T细胞）和非胸腺依赖性淋巴细胞（B细胞）在人体对疟疾免疫反应中的作用。尽管巨噬细胞的吞噬作用是疟疾的一个重要特征，但这些细胞与T细胞和B细胞之间全面的协作程度尚不清楚。目前，关于T细胞发挥重要防御作用的证据并不令人信服。另一方面，B细胞在免疫球蛋白和特定抗体的合成中发挥着重要作用，并对可能影响其活性的因素进行了探讨。文中描述了血清中疟疾抗体的不同流行病学模式，并强调了将可靠的抗体检测试验作为疟疾调查技术常规组成部分的必要性，特别是在频繁使用抗疟药物的地区。
