• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

新生儿的蓝斑、去甲肾上腺素与记忆

The locus coeruleus, norepinephrine, and memory in newborns.

作者信息

Sullivan R M, Wilson D A

机构信息

Department of Zoology, University of Oklahoma, Norman 73019.

出版信息

Brain Res Bull. 1994;35(5-6):467-72. doi: 10.1016/0361-9230(94)90160-0.

DOI:10.1016/0361-9230(94)90160-0
PMID:7859104
Abstract

Use of learned odor cues by newborn rats is critical for pup survival. Rat pups acquire approach responses to maternal odors through an associative conditioning mechanism. This learned behavioral response is accompanied by a modification of olfactory bulb neural response patterns to the learned odor. Both the behavioral and neural response changes involved and require norepinephrine release in the olfactory bulb. The source of this norepinephrine is the locus coeruleus. It is proposed that the unique response properties of the locus coeruleus during the early postnatal period in the rat may facilitate acquisition of these critical early memories.

摘要

新生大鼠对习得气味线索的利用对幼崽的生存至关重要。幼鼠通过关联学习机制获得对母体气味的趋近反应。这种习得的行为反应伴随着嗅球神经反应模式对习得气味的改变。行为和神经反应的变化都涉及且需要嗅球中去甲肾上腺素的释放。这种去甲肾上腺素的来源是蓝斑核。有人提出,大鼠出生后早期蓝斑核的独特反应特性可能有助于获取这些关键的早期记忆。

相似文献

1
The locus coeruleus, norepinephrine, and memory in newborns.新生儿的蓝斑、去甲肾上腺素与记忆
Brain Res Bull. 1994;35(5-6):467-72. doi: 10.1016/0361-9230(94)90160-0.
2
Bilateral 6-OHDA lesions of the locus coeruleus impair associative olfactory learning in newborn rats.蓝斑的双侧6-羟基多巴胺损伤会损害新生大鼠的联合嗅觉学习能力。
Brain Res. 1994 Apr 18;643(1-2):306-9. doi: 10.1016/0006-8993(94)90038-8.
3
The neurobiology of infant maternal odor learning.婴儿母婴气味学习的神经生物学。
Braz J Med Biol Res. 2010 Oct;43(10):914-9. doi: 10.1590/s0100-879x2010007500090. Epub 2010 Sep 10.
4
Early-life stress disrupts attachment learning: the role of amygdala corticosterone, locus ceruleus corticotropin releasing hormone, and olfactory bulb norepinephrine.早期生活压力会破坏依恋学习:杏仁核皮质酮、蓝斑促肾上腺皮质激素释放激素和嗅球去甲肾上腺素的作用。
J Neurosci. 2009 Dec 16;29(50):15745-55. doi: 10.1523/JNEUROSCI.4106-09.2009.
5
Association of an odor with activation of olfactory bulb noradrenergic beta-receptors or locus coeruleus stimulation is sufficient to produce learned approach responses to that odor in neonatal rats.将一种气味与嗅球去甲肾上腺素能β受体的激活或蓝斑刺激相关联,足以使新生大鼠对该气味产生习得性趋近反应。
Behav Neurosci. 2000 Oct;114(5):957-62. doi: 10.1037/0735-7044.114.5.957.
6
Developing a sense of safety: the neurobiology of neonatal attachment.建立安全感:新生儿依恋的神经生物学
Ann N Y Acad Sci. 2003 Dec;1008:122-31. doi: 10.1196/annals.130.013.
7
The biphasic effects of locus coeruleus noradrenergic activation on dendrodendritic inhibition in the rat olfactory bulb.蓝斑去甲肾上腺素能激活对大鼠嗅球树突-树突抑制的双相作用。
Brain Res. 1998 Feb 9;783(2):272-9. doi: 10.1016/s0006-8993(97)01371-1.
8
Unique neural circuitry for neonatal olfactory learning.新生儿嗅觉学习的独特神经回路。
J Neurosci. 2004 Feb 4;24(5):1182-9. doi: 10.1523/JNEUROSCI.4578-03.2004.
9
Postnatal development of the noradrenergic projection from locus coeruleus to the olfactory bulb in the rat.大鼠蓝斑去甲肾上腺素能投射至嗅球的生后发育
J Comp Neurol. 1991 Feb 15;304(3):467-77. doi: 10.1002/cne.903040310.
10
Mitral cell beta1 and 5-HT2A receptor colocalization and cAMP coregulation: a new model of norepinephrine-induced learning in the olfactory bulb.二尖瓣细胞β1与5-HT2A受体共定位及环磷酸腺苷共同调节:嗅球中去甲肾上腺素诱导学习的新模型
Learn Mem. 2003 Jan-Feb;10(1):5-15. doi: 10.1101/lm.54803.

引用本文的文献

1
Mother-young bond in non-human mammals: Neonatal communication pathways and neurobiological basis.非人类哺乳动物中的母婴关系:新生儿交流途径及神经生物学基础。
Front Psychol. 2022 Nov 29;13:1064444. doi: 10.3389/fpsyg.2022.1064444. eCollection 2022.
2
Why Would the Brain Need Dormant Neuronal Precursors?大脑为何需要休眠的神经元前体细胞?
Front Neurosci. 2022 Apr 8;16:877167. doi: 10.3389/fnins.2022.877167. eCollection 2022.
3
Social Regulation of Negative Valence Systems During Development.发育过程中负性情绪系统的社会调节
Front Syst Neurosci. 2022 Jan 20;15:828685. doi: 10.3389/fnsys.2021.828685. eCollection 2021.
4
Electrical stimulation of cranial nerves in cognition and disease.颅神经电刺激在认知和疾病中的应用。
Brain Stimul. 2020 May-Jun;13(3):717-750. doi: 10.1016/j.brs.2020.02.019. Epub 2020 Feb 23.
5
Genesis and Maintenance of Attentional Biases: The Role of the Locus Coeruleus-Noradrenaline System.注意偏向的产生和维持:蓝斑-去甲肾上腺素系统的作用。
Neural Plast. 2017;2017:6817349. doi: 10.1155/2017/6817349. Epub 2017 Jul 20.
6
Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior.婴儿依恋敏感期的早期生活逆境:威胁处理和社会行为的行为神经生物学编程。
Dev Cogn Neurosci. 2017 Jun;25:145-159. doi: 10.1016/j.dcn.2017.02.002. Epub 2017 Feb 16.
7
Neurogenetic variations in norepinephrine availability enhance perceptual vividness.去甲肾上腺素可用性的神经遗传变异增强了感知清晰度。
J Neurosci. 2015 Apr 22;35(16):6506-16. doi: 10.1523/JNEUROSCI.4489-14.2015.
8
Early life trauma and attachment: immediate and enduring effects on neurobehavioral and stress axis development.早期生活创伤与依恋:对神经行为和应激轴发育的即时及持久影响。
Front Endocrinol (Lausanne). 2014 Mar 21;5:33. doi: 10.3389/fendo.2014.00033. eCollection 2014.
9
Neurobiology of secure infant attachment and attachment despite adversity: a mouse model.安全型婴儿依恋和逆境中依恋的神经生物学:一种小鼠模型。
Genes Brain Behav. 2013 Oct;12(7):673-80. doi: 10.1111/gbb.12067. Epub 2013 Aug 23.
10
The development and neurobiology of infant attachment and fear.婴儿依恋和恐惧的发展与神经生物学
Dev Neurosci. 2012;34(2-3):101-14. doi: 10.1159/000336732. Epub 2012 May 8.