Sullivan R M, Stackenwalt G, Nasr F, Lemon C, Wilson D A
Department of Zoology, University of Oklahoma, Norman 73019, USA.
Behav Neurosci. 2000 Oct;114(5):957-62. doi: 10.1037/0735-7044.114.5.957.
These experiments examined the sufficiency of pairing an odor with either intrabulbar activation of noradrenergic beta-receptors or pharmacological stimulation of the locus coeruleus to support learned odor preferences in Postnatal Day 6-7 rat pups. The results showed that pups exposed to odor paired with beta-receptor activation limited to the olfactory bulb (isoproterenol, 50 microM) displayed a conditioned approach response on subsequent exposure to that odor. Furthermore, putative stimulation of the locus coeruleus (2 microM idazoxan or 2 mM acetylcholine) paired with odor produced a subsequent preference for that odor. The effects of locus coeruleus stimulation could be blocked by a pretraining injection of the beta-receptor antagonist propranolol (20 mg/kg). Together these results suggest that convergence of odor input with norepinephrine release from the locus coeruleus terminals within the olfactory bulb is sufficient to support olfactory learning.
这些实验研究了将一种气味与嗅球内去甲肾上腺素能β受体的激活或蓝斑的药理学刺激配对，是否足以支持出生后第6 - 7天的大鼠幼崽形成习得性气味偏好。结果表明，暴露于与仅限于嗅球的β受体激活（异丙肾上腺素，50微摩尔）配对的气味中的幼崽，在随后接触该气味时表现出条件性趋近反应。此外，与气味配对的假定蓝斑刺激（2微摩尔咪唑克生或2毫摩尔乙酰胆碱）会使幼崽随后对该气味产生偏好。蓝斑刺激的作用可被预训练注射β受体拮抗剂普萘洛尔（20毫克/千克）阻断。这些结果共同表明，气味输入与来自嗅球内蓝斑终末的去甲肾上腺素释放的汇聚足以支持嗅觉学习。
