Bozzette S A, Hays R D, Berry S H, Kanouse D E, Wu A W
Health Sciences Program, RAND, Santa Monica, CA 90407.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):253-65. doi: 10.1097/00042560-199503010-00006.
Health status measures adapted from the Medical Outcomes Study (MOS) scales have been shown to be useful and highly reliable in human immunodeficiency virus-infected populations, but acceptance of these measures has been limited in part by concerns over investigator, patient, and data burden. We sought to address these concerns by reducing the number of items in the MOS scales rather than by reducing the number of domains covered. We selected items for the shorter scales based on the static and dynamic relationships to the longer scales and to indicators of clinical and functional status in 10,399 responses from 1,934 participants, as well as in relevant subpopulations. The resulting scales have a total of 21 items, as compared to 38 in the longer instrument. Correlations between the shorter and longer scales were excellent. At 0.78 to 0.85, the reliability of the subscales was lower than that of the full scales. However, compared to an index based on the longer scales, an index based on the subscales had identical reliability, yielded nearly identical values, and was as sensitive in detecting treatment differences in a clinical trial. The resulting instrument continues to cover disability, work, utilization, and health status, but is less than half the length of our previous comprehensive questionnaires.
源自医学结局研究（MOS）量表的健康状况测量方法，已被证明在人类免疫缺陷病毒感染人群中是有用且高度可靠的，但这些测量方法的接受度在一定程度上受到对研究者、患者和数据负担担忧的限制。我们试图通过减少MOS量表中的条目数量而非减少所涵盖的领域数量来解决这些担忧。我们根据与较长量表以及1934名参与者的10399份回复中的临床和功能状态指标的静态和动态关系，为较短量表选择条目，相关亚组情况也同样如此。最终形成的量表共有21个条目，而较长的量表有38个条目。较短量表与较长量表之间的相关性非常好。分量表的信度在0.78至0.85之间，低于总量表。然而，与基于较长量表的指数相比，基于分量表的指数具有相同的信度，得出的数值几乎相同，并且在检测临床试验中的治疗差异时同样敏感。最终形成的工具仍涵盖残疾、工作、医疗利用情况和健康状况，但长度不到我们之前综合问卷的一半。
