Milman N, Larsen L
Acta Med Scand. 1976;200(1-2):25-30. doi: 10.1111/j.0954-6820.1976.tb08191.x.
Gastrointestinal iron absorption has been measured by means of whole body counting in 13 patients after renal allotransplantation. Whole body retention 14 days after oral administration of 10 muCi 59Fe together with a carrier dose of 9.9 mg Fe2+ was used as an expression of absorption. The percentage incorporation in the total erythrocyte mass of administered 59Fe (erythrocyte incorporation) and absorbed 59Fe (red cell utilization) was estimated as well. Geometric mean iron absorption was 12.4 +/- 2.5 (S.D.)% and geometric mean erythrocyte incorporation 11.1 +/- 3.0 (S.D.)% while arithmetic mean red cell utilization was 95.6 +/- 8.6 (S.E.M.)%. None of these parameters differed significantly from those obtained in normal subjects (p greater than 0.2, p greater than 0.1, pgreater than 0.3, respectively). Iron absorption and erythrocyte incorporation in renal transplanted patients did not differ significantly from the values measured in non-dialysed and dialysed patients with chronic renal failure (p greather than 0.1). The correlation between iron absorption and erythrocyte incorporation was highly significant (r = 0.96, p less than 0.001).
通过全身计数法对13例同种异体肾移植患者的胃肠道铁吸收情况进行了测定。口服10微居里59铁并同时给予9.9毫克亚铁离子载体剂量后14天的全身铁潴留量被用作吸收情况的一种指标。同时还估算了所给予的59铁在总红细胞量中的掺入百分比（红细胞掺入率）以及吸收的59铁在红细胞中的利用率（红细胞利用率）。几何平均铁吸收率为12.4±2.5（标准差）%，几何平均红细胞掺入率为11.1±3.0（标准差）%，而算术平均红细胞利用率为95.6±8.6（标准误）%。这些参数与正常受试者所获得的参数相比均无显著差异（分别为p＞0.2、p＞0.1、p＞0.3）。肾移植患者的铁吸收和红细胞掺入率与慢性肾衰竭未透析和透析患者所测得的值相比无显著差异（p＞0.1）。铁吸收与红细胞掺入率之间的相关性非常显著（r = 0.96，p＜0.001）。
