Da Silva Cardoso M, Epple S, Koerner K, Kubanek B
German Red Cross Blood Bank Ulm, University of Ulm.
Eur J Epidemiol. 1994 Oct;10(5):637-40. doi: 10.1007/BF01719585.
In this study we compared the nucleotide sequence of the 5' NC-region of the HCV genome isolated from seven patients and two blood donors from Southern Germany. We could identify two very distinct groups of isolates: the first very similar to the HCV prototype sequence (HCV1) with homology ranging from 99.5% to 98.7%; the second showing 91.7% homology to the HCV1. Group 1 isolates could be found in five patients and the two blood donors. Group 2 isolates could be found in the two other patients. Finally, we could observe neither nucleotide insertion nor deletion in the isolates described here.
在本研究中，我们比较了从德国南部七名患者和两名献血者中分离出的丙型肝炎病毒（HCV）基因组5'非编码区的核苷酸序列。我们能够识别出两组非常不同的分离株：第一组与HCV原型序列（HCV1）非常相似，同源性在99.5%至98.7%之间；第二组与HCV1的同源性为91.7%。第一组分离株存在于五名患者和两名献血者中。第二组分离株存在于另外两名患者中。最后，我们在此描述的分离株中未观察到核苷酸插入或缺失。
