Dawkins R L, O'Reilly C, Grimsley G, Ziko P J
Ann N Y Acad Sci. 1976;274:461-7. doi: 10.1111/j.1749-6632.1976.tb47707.x.
To evaluate further the association between myasthenia gravis and humoral immune deficiency, 92 sera from myasthenic patients were tested so as to determine titers against commensal E. coli, isohemagglutinin titers, and IgG and IgM concentrations. Results were compared with those obtained from normals, disease controls, and W27 positive arthropathy. On the basis of these three investigations it is concluded that subtle immunodeficiency is common in myasthenia gravis, and it is suggested that an immune defect might explain such diverse associations as thymic disease, HL-A antigens, and various autoimmune phenomena.
为了进一步评估重症肌无力与体液免疫缺陷之间的关联，检测了92例重症肌无力患者的血清，以确定其针对共生大肠杆菌的滴度、同种血凝素滴度以及IgG和IgM浓度。将结果与正常人群、疾病对照人群以及W27阳性关节病患者的结果进行了比较。基于这三项研究得出结论，轻微免疫缺陷在重症肌无力中很常见，并且有人提出免疫缺陷可能解释诸如胸腺疾病、HL - A抗原以及各种自身免疫现象等多种关联。
