Simon P, Ramée M P, Autuly V, Laruelle E, Charasse C, Cam G, Ang K S
Laboratoire d'Anatomie Pathologique, Centre Hospitalier et Universitaire Rennes, France.
Kidney Int. 1994 Oct;46(4):1192-8. doi: 10.1038/ki.1994.384.
Between January 1, 1976 and December 31, 1990, histological diagnosis of primary glomerular diseases (PGD) was made in 480 patients born and living at the time of diagnosis in a region of France, comprising 410,664 inhabitants, of whom 390,574 were aged from 10 to 80 years. The prevalence of PGD during a 70 year exposure to risk (10 to 80 years of age) was evaluated to 5.7 in 1000 (7.6 in 1000 males and 3.8 in 1000 females). The most common PGD was IgA nephropathy with a prevalence of 1.9 in 1000 (3.3 in 1000 males, 1 in 1000 females). The annual incidence of the disease was evaluated separately for three consecutive five-year periods: period A (1976-80), period B (1981-85), and period C (1986-90). Within each of these three periods the number of patients with PGD was 179, 170 and 131, respectively, and annual incidence was 9.3, 8.8 and 6.7 in 100,000. The incidence of IgA nephropathy remained the same throughout the three periods: 2.6, 3.1 and 2.5 in 100,000. The incidence of membranoproliferative glomerulonephritis decreased from 1981 onward (0.9, 0.5 and 0.15 in 100,000), while that of membranous nephropathy increased slightly (1.2, 1.6 and 1.7 in 100,000). Acute streptococcal glomerulonephritis virtually disappeared during periods B and C. Lipoid nephrosis was less frequent in period C and idiopathic proliferative glomerulonephritis with crescents slightly increased (0.3, 0.4 and 0.6 in 100,000). There was no significant difference between the three periods regarding the incidence of other PGD.(ABSTRACT TRUNCATED AT 250 WORDS)
1976年1月1日至1990年12月31日期间，法国某地区对480例在诊断时出生并居住于此的原发性肾小球疾病（PGD）患者进行了组织学诊断。该地区有410,664名居民，其中390,574名年龄在10至80岁之间。在70年的风险暴露期（10至80岁）内，PGD的患病率评估为千分之5.7（男性为千分之7.6，女性为千分之3.8）。最常见的PGD是IgA肾病，患病率为千分之1.9（男性为千分之3.3，女性为千分之1）。该疾病的年发病率分别针对连续三个五年期进行评估：A期（1976 - 1980年）、B期（1981 - 1985年）和C期（1986 - 1990年）。在这三个时期内，PGD患者数量分别为179例、170例和131例，年发病率分别为十万分之9.3、十万分之8.8和十万分之6.7。IgA肾病在这三个时期的发病率保持不变：十万分之2.6、十万分之3.1和十万分之2.5。膜增生性肾小球肾炎的发病率从1981年起下降（十万分之0.9、十万分之0.5和十万分之0.15），而膜性肾病的发病率略有上升（十万分之1.2、十万分之1.6和十万分之1.7）。急性链球菌性肾小球肾炎在B期和C期几乎消失。脂性肾病在C期较少见，伴有新月体的特发性增生性肾小球肾炎略有增加（十万分之0.3、十万分之0.4和十万分之0.6）。在其他PGD的发病率方面，这三个时期之间没有显著差异。（摘要截断于250字）
