Heckmatt J Z
Arch Dis Child. 1976 Aug;51(8):569-75. doi: 10.1136/adc.51.8.569.
Thirty-six patients with coliform meningitis in the 15-year period 1960-1974 are reported. Only 9 patients survived unscathed though the other 5 survivors were not seriously affected. During the septicaemic phase of the illness the cerebrospinal fluid (CSF), though positive on culture, may be otherwise normal. Meningitis can ensue even when the patient is receiving antibiotics to which the organism is sensitive and the possible disadvantages of using a nondiffusible antibiotic must be appreciated. The CSF in Esch. coli meningitis can be persistently haemorrhagic which may cause difficulties in the initial diagnosis. It must be emphasized that infective illness in the newborn is often nonspecific in its presentation and that repeated bacteriological investigations are essential in neonates who are unwell.
本文报告了1960年至1974年这15年间36例大肠埃希菌脑膜炎患者。只有9例患者完全康复，另外5例幸存者虽未受到严重影响。在疾病的败血症阶段，脑脊液（CSF）虽然培养呈阳性，但其他方面可能正常。即使患者正在接受对该病原体敏感的抗生素治疗，仍可能发生脑膜炎，必须认识到使用非扩散性抗生素可能存在的弊端。大肠杆菌脑膜炎患者的脑脊液可能持续出血，这可能给早期诊断带来困难。必须强调的是，新生儿感染性疾病的表现往往不具有特异性，对于身体不适的新生儿，反复进行细菌学检查至关重要。
