Castañón C, Amigo M C, Bañales J L, Nava A, Reyes P A
Department of Ophthalmology, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan, Mexico.
Ophthalmology. 1995 Feb;102(2):256-62. doi: 10.1016/s0161-6420(95)31028-7.
To evaluate the ocular involvement in patients with the primary antiphospholipid syndrome.
The authors performed a cross-sectional ophthalmologic study of 17 patients with the primary antiphospholipid syndrome. Retinal fluorangiography was performed in 13 patients.
Visual symptoms were described by ten patients. Visual acuity was markedly decreased in five eyes. Conjunctival telangiectases and microaneurysms, in addition to single instances of bilateral episcleritis and limbal keratitis, were the anterior segment findings. Fundus abnormalities were present in 15 patients. Venous tortuosity was the most common finding but there were instances of optic disc edema, vitreous hemorrhages, cotton-wool spots, vitreous bands, serous detachment of the macula, and retinal capillary abnormalities. Fluorangiography showed vaso-occlusive retinopathy in six eyes (5 patients, 29%). Choriocapillary vessel occlusion was observed in two eyes (1 patient) and binocular reticular degeneration of pigmentary epithelium was present in another case.
The eye is frequently involved in the primary antiphospholipid syndrome, and serious ocular damage may occur. Detailed ophthalmologic evaluation is warranted in these patients.
评估原发性抗磷脂综合征患者的眼部受累情况。
作者对17例原发性抗磷脂综合征患者进行了横断面眼科研究。13例患者进行了视网膜荧光血管造影。
10例患者描述有视觉症状。5只眼视力明显下降。眼前节表现包括结膜毛细血管扩张和微动脉瘤，以及双侧巩膜炎和角膜缘角膜炎各1例。15例患者存在眼底异常。静脉迂曲是最常见的表现，但也有视神经盘水肿、玻璃体积血、棉絮斑、玻璃体条索、黄斑浆液性脱离和视网膜毛细血管异常的情况。荧光血管造影显示6只眼（5例患者，29%）出现血管闭塞性视网膜病变。2只眼（1例患者）观察到脉络膜毛细血管血管闭塞，另1例出现双眼色素上皮网状变性。
原发性抗磷脂综合征常累及眼部，可能发生严重的眼部损害。这些患者需要进行详细的眼科评估。
