Richer J P, Silvain C, Rouffineau J, Péchier F, Caritez J C, Kamina P, Carretier M
Groupe de Recherche en Transplantation Multiviscérale (GRMTV), Faculté de Médecine, Poitiers, France.
Surg Radiol Anat. 1994;16(3):245-51. doi: 10.1007/BF01627678.
In order to assess the tolerance induced by hepatic transplantation in a multivisceral graft, a model of a transplant combining the liver and small intestine was developed in the pig, using animals of Large White Isogroup O, typed in the system of major incompatibility as "Swine lymphocyte antigen" (SLA), whose weight varied from 30 to 40 kg. In order to limit the duration of warm ischemia, dissection of the graft was performed on the donor animal with respect for the following anatomic features: absence of intestinal attachment to the posterior parietal peritoneum, anti-clockwise torsion of 360 degrees of the intestine around the superior mesenteric a. with the small intestine convolutions on the right and the colonic helix on the left. The bifid pancreas follows this rotation and its resection must respect the vascularisation of the proximal small intestine; the hepatic a. arises from a common trunk with a gastrosplenic branch of the aorta between the crura of the diaphragm and travels sagittally from behind forward toward the liver pedicle, which it reaches ar the upper border of the duodenum; the hepatic a. and its branches are dorsal in relation to the portal vein; the hepatic arterial distribution follows a right-left and antero-posterior systematisation for the six hepatic lobes of this quadruped animal.
为了评估多脏器移植中肝脏移植诱导的耐受性，在猪身上建立了一种肝脏和小肠联合移植模型，使用大白O同基因群的猪，其在主要不相容系统中分型为“猪淋巴细胞抗原”（SLA），体重在30至40千克之间。为了限制热缺血时间，在供体动物身上进行移植物解剖时，需遵循以下解剖学特征：小肠无附着于后腹膜壁层，小肠围绕肠系膜上动脉逆时针扭转360度，小肠袢位于右侧，结肠螺旋位于左侧。双歧胰腺跟随这种旋转，其切除必须注意近端小肠的血管供应；肝动脉起源于与主动脉胃脾分支的共同干，位于膈脚之间，从后向前呈矢状走行至肝蒂，在十二指肠上缘到达肝蒂；肝动脉及其分支相对于门静脉位于背侧；对于这种四足动物的六个肝叶，肝动脉分布遵循左右和前后系统化。
