Wesche D, Lutz S, Barnish G
Immanuel Lutheran Hospital, Wapenamanda, Enga Province, Papua New Guinea.
P N G Med J. 1994 Mar;37(1):12-4.
Chewable pyrantel pamoate tablets were administered to children randomly assigned to three treatment groups. Individuals in each group were instructed either to swallow whole, to chew and swallow, or to swallow previously pulverized tablets. With respect to Ascaris, results of posttreatment stool examinations indicated no differences in cure rates and egg reduction rates between the different modes of treatment. However, for both hookworm and Trichuris, mean egg counts increased for both swallow and chew groups, but decreased in the pulverized group. In addition to the highest egg reduction rates, the most parasitological cures were also seen in the pulverized group for these two worms. The status of standards for chewable tablets is discussed. Until the standards are changed it is recommended that all chewable tablets be crushed before swallowing.
将可咀嚼的双羟萘酸噻嘧啶片剂给予随机分配到三个治疗组的儿童。每组中的个体被指示要么整片吞服、咀嚼并吞服，要么吞服先前研碎的片剂。关于蛔虫，治疗后粪便检查结果表明不同治疗方式之间的治愈率和虫卵减少率没有差异。然而，对于钩虫和鞭虫，吞服组和咀嚼组的平均虫卵计数均增加，但研碎组的平均虫卵计数减少。除了最高的虫卵减少率外，这两种蠕虫的研碎组中寄生虫学治愈的情况也最为常见。文中讨论了可咀嚼片剂的标准状况。在标准改变之前，建议所有可咀嚼片剂在吞服前研碎。
