正常椎间盘的对比增强：时间和剂量依赖性。
Contrast enhancement of normal intervertebral disks: time and dose dependence.
作者信息
Ibrahim M A, Jesmanowicz A, Hyde J S, Estkowski L, Haughton V M
机构信息
Biophysics Research Institute, Medical College of Wisconsin, Milwaukee.
出版信息
AJNR Am J Neuroradiol. 1994 Mar;15(3):419-23.
PURPOSE
To determine the dose of contrast medium and the imaging strategy sufficient to detect diffusion of low-molecular-weight gadolinium-containing contrast media into normal intervertebral disks.
METHODS
In 11 rabbits, sequential MR images were obtained of the spine for 120 minutes after intravenous injection of gadopentetate dimeglumine in doses of 0.1 to 2.8 mmol/kg. Images were inspected for evidence of contrast enhancement. Signal intensity was measured and plotted as a function of time and dose.
RESULTS
Contrast enhancement was detected by inspection of images and by measurement in animals receiving doses of 0.3 mmol/kg and larger.
CONCLUSIONS
Diffusion of gadolinium-containing chelates into the intervertebral disk can be detected with clinically used doses of commercially available contrast medium. Therefore, with MR and a gadolinium-containing contrast medium, diffusion into intervertebral disks can be studied.
目的
确定足以检测低分子量含钆造影剂向正常椎间盘扩散的造影剂剂量及成像策略。
方法
给11只兔子静脉注射剂量为0.1至2.8 mmol/kg的钆喷酸葡胺后，连续120分钟获取脊柱的磁共振图像。检查图像是否有造影剂增强的迹象。测量信号强度并将其绘制为时间和剂量的函数。
结果
在接受剂量为0.3 mmol/kg及以上的动物中，通过图像检查和测量检测到造影剂增强。
结论
使用市售造影剂的临床常用剂量可检测到含钆螯合物向椎间盘的扩散。因此，利用磁共振成像和含钆造影剂，可以研究造影剂向椎间盘的扩散情况。
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