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Positive immunostaining for platelet derived growth factor (PDGF) is an adverse prognostic factor in patients with advanced breast cancer.

作者信息

Seymour L, Bezwoda W R

机构信息

Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.

出版信息

Breast Cancer Res Treat. 1994;32(2):229-33. doi: 10.1007/BF00665774.

DOI:10.1007/BF00665774
PMID:7865852
Abstract

Previous studies suggest a prognostic role for PDGF in patients with breast cancer, with patients with high plasma PDGF levels or positive response to therapy. We have examined a further 58 patients with advanced breast cancer for the presence of tissue PDGF immunostaining. Patients displaying positive tissue immunostaining for PDGF had a highly significant shorter survival (p = 0.002) than patients with no immunostaining. In addition PDGF positive patients treated with combination chemotherapy had a significantly lower response rate (p = 0.05) than PDGF negative patients. These results confirm our previous findings that PDGF may be an important indicator of shortened survival and treatment failure in patients with advanced breast cancer.

摘要

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TGF-beta stimulates rat mesangial cell proliferation in culture: role of PDGF beta-receptor expression.转化生长因子-β刺激培养的大鼠系膜细胞增殖：血小板衍生生长因子β受体表达的作用
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胶质母细胞瘤蛋白质组的生态位去卷积揭示了在神经前转录组亚群内的独特浸润表型。
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P68 RNA Helicase facilitates Breast Cancer progression by promoting Proliferation and Migration via PDGFR-β/AR axis.P68 RNA解旋酶通过PDGFR-β/AR轴促进增殖和迁移，从而推动乳腺癌进展。
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6
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