Rebuffé-Serive M, Hendler R, Bracero N, Cummunigs N, McCarthy S, Rodin J
Department of Psychology, Yale University, New Haven, Connecticut 06520-8205.
Int J Obes Relat Metab Disord. 1994 Oct;18(10):651-8.
An association between weight cycling and mortality and morbidity has been pointed out in epidemiological studies. However, the mechanisms underlying this association are difficult to demonstrate, and earlier studies have been contradictory. In this work we investigated several mechanisms which have been suggested as possible mediators for the association between weight cycling and a number of prevalent diseases. Fat consumption, fat preference, fat distribution and metabolism, lipid profile, oral glucose tolerance test (OGTT), blood pressure and steroid hormone determinations were performed in 28 women with or without a weight cycling history, who were matched for weight and age. No differences were found between cyclers and non-cyclers for any of the behavioral, physiological, metabolical and health parameters measured, with the exception of an increase in subcutaneous abdominal fat in the cyclers. It was concluded that, in generally healthy young women, weight cycling does not differentially increase risk factors that are harmful for health. However adverse effects might still be detectable in situations where women are biologically challenged.
流行病学研究指出了体重循环与死亡率及发病率之间的关联。然而，这种关联背后的机制难以证实，早期研究结果相互矛盾。在这项研究中，我们调查了几种被认为可能是体重循环与多种常见疾病之间关联的潜在介导因素的机制。对28名有或没有体重循环史的女性进行了脂肪消耗、脂肪偏好、脂肪分布与代谢、血脂谱、口服葡萄糖耐量试验（OGTT）、血压及类固醇激素测定，这些女性在体重和年龄上相匹配。除了体重循环者腹部皮下脂肪增加外，在测量的任何行为、生理、代谢和健康参数方面，体重循环者与非体重循环者之间均未发现差异。研究得出结论，在一般健康的年轻女性中，体重循环并不会差异性地增加对健康有害的风险因素。然而，在女性面临生理挑战的情况下，可能仍能检测到不良影响。
