Muls E, Kempen K, Vansant G, Saris W
Department of Endocrinology, Metabolism and Nutrition, University Hospital Gasthuisberg, Catholic University Leuven, Belgium.
Int J Obes Relat Metab Disord. 1995 Sep;19 Suppl 3:S46-50.
Weight cycling has been hypothesized to have deleterious metabolic, behavioral and health consequences. The majority of clinical studies in humans do however not support the hypothesis that weight cycling per se influences the amount of velocity of subsequent weight loss. Both natural and experimental weight cycling studies have failed to demonstrate permanent alterations of body composition or body fat distribution. Studies found little evidence that weight cycling affects resting energy expenditure. Further research on postulated effects of weight cycling on other components of energy expenditure is needed. A history of weight cycling is not related to alterations in fat mobilization or in cardiovascular risk factors such as blood pressure and serum lipids, but weight variability may be associated with decreases in glucose tolerance over time. The potential impact of weight cycling on dietary preference for fat, on psychological adjustment or on disordered eating behavior, including binge eating, deserves further investigation. The data from large epidemiological databases suggesting a link between body weight fluctuation and excess mortality are sufficiently provocative to encourage further research into the association, but do not override the potential benefits of weight loss in obese patients.
体重循环被认为会产生有害的代谢、行为和健康后果。然而，大多数针对人类的临床研究并不支持体重循环本身会影响后续体重减轻的速度这一假设。自然发生的和实验性的体重循环研究均未能证明身体成分或体脂分布会发生永久性改变。研究发现几乎没有证据表明体重循环会影响静息能量消耗。需要对体重循环对能量消耗其他组成部分的假定影响进行进一步研究。体重循环史与脂肪动员或心血管危险因素（如血压和血脂）的改变无关，但体重变化可能会随着时间的推移与葡萄糖耐量降低有关。体重循环对脂肪饮食偏好、心理调适或包括暴饮暴食在内的饮食紊乱行为的潜在影响值得进一步研究。来自大型流行病学数据库的数据表明体重波动与过高死亡率之间存在联系，这足以激发人们对这种关联进行进一步研究，但这并不否定肥胖患者减肥的潜在益处。
