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Capillary electrophoresis and capillary electrophoresis-mass spectrometry in drug and metabolite analysis.

作者信息

Naylor S, Tomlinson A J, Benson L M, Gorrod J W

机构信息

Department of Biochemistry and Molecular Biology, Guggenheim Mayo Clinic, Rochester, MN 55905.

出版信息

Eur J Drug Metab Pharmacokinet. 1994 Jul-Sep;19(3):235-40. doi: 10.1007/BF03188926.

DOI:10.1007/BF03188926
PMID:7867666
Abstract

The structural diversity of modern therapeutic agents can lead to labour intensive method development for each drug and the structural characterization of their metabolites. In this work, we show the benefits of the high resolution capabilities of capillary electrophoresis (CE) and demonstrate that nonaqueous CE and on-line CE-mass spectrometry (CE-MS) leads to enhanced resolution and recovery of mixtures containing the prototype H2-antagonist, mifentidine, and putative metabolites. Furthermore, the usefulness of CE-tandem MS (CE-MS/MS) is also demonstrated by the structural characterization of the novel N2-hydroxylamine metabolite of mifentidine.

摘要

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引用本文的文献

1
In vitro studies on the metabolic fate of mifentidine, a novel histamine H2-receptor antagonist.新型组胺H2受体拮抗剂米芬替丁代谢命运的体外研究
Eur J Drug Metab Pharmacokinet. 1997 Apr-Jun;22(2):155-64. doi: 10.1007/BF03189800.
2
Capillary electrophoresis in pharmaceutical analysis.药物分析中的毛细管电泳
Pharm Res. 1997 Apr;14(4):372-87. doi: 10.1023/a:1012018709641.

本文引用的文献

1
Capillary electrophoresis: a powerful microanalytical technique for biologically active molecules.毛细管电泳：一种用于生物活性分子的强大微量分析技术。
Biotechniques. 1993 Jan;14(1):98-111.
2
Investigation of the metabolic fate of the neuroleptic drug haloperidol by capillary electrophoresis-electrospray ionization mass spectrometry.采用毛细管电泳-电喷雾电离质谱法研究抗精神病药物氟哌啶醇的代谢命运。
J Chromatogr. 1993 Nov 24;621(2):239-48. doi: 10.1016/0378-4347(93)80101-9.
3
Investigation of the metabolism of the neuroleptic drug haloperidol by capillary electrophoresis.
通过毛细管电泳法对神经安定药物氟哌啶醇代谢情况的研究。
J Chromatogr A. 1993 Oct 22;652(2):417-26. doi: 10.1016/0021-9673(93)83261-P.
4
Investigation of drug metabolism using capillary electrophoresis with photodiode array detection and online mass spectrometry equipped with an array detector.使用配备光电二极管阵列检测的毛细管电泳和配备阵列检测器的在线质谱法进行药物代谢研究。
Electrophoresis. 1994 Jan;15(1):62-71. doi: 10.1002/elps.1150150110.
5
Investigation of the in vitro metabolism of the H2-antagonist mifentidine by on-line capillary electrophoresis-mass spectrometry using non-aqueous separation conditions.使用非水分离条件，通过在线毛细管电泳-质谱联用技术对H2拮抗剂米芬替丁的体外代谢进行研究。
J Chromatogr B Biomed Appl. 1994 Jul 15;657(2):373-81. doi: 10.1016/0378-4347(94)00142-1.
6
High-performance liquid chromatographic comparison of in vivo and in vitro drug metabolism.体内和体外药物代谢的高效液相色谱比较
J Chromatogr. 1984 May 4;290:1-12. doi: 10.1016/s0021-9673(01)93556-3.
7
Separation of serotonin from catechols by capillary zone electrophoresis with electrochemical detection.采用电化学检测的毛细管区带电泳法分离血清素和儿茶酚。
Anal Chem. 1989 Jan 15;61(2):98-100. doi: 10.1021/ac00177a004.