酿酒酵母小菌落菌株的诱变活性。
Mutator activity of petite strains of Saccharomyces cerevisiae.
作者信息
Flury F, von Borstel R C, Williamson D H
出版信息
Genetics. 1976 Aug;83(4):645-53. doi: 10.1093/genetics/83.4.645.
Abstract
Petite strains in Saccharomyces exhibit enhanced spontaneous mutation rates of nuclear genes regardless of whether they are cytoplasmically or nuclearly inherited, or whether or not the cytoplasmic petite strains have mitochondrial DNA. In petite strains, the mutation rate for the nonsense allele lys1-1 is enhanced by a factor of 3-6 and for the missense allele his1-7 by a factor of 2 as compared with their grande counterparts. The reversion of a third allele, the putative frameshift mutation, hom3-10, is not enhanced in a petite background. The results indicate that the spontaneous mutation rate of an organism can be altered by indirect intracellular influences.
摘要
酿酒酵母中的小菌落菌株表现出核基因自发突变率升高，无论这些基因是细胞质遗传还是核遗传，也无论细胞质小菌落菌株是否含有线粒体DNA。与它们的大菌落对应菌株相比，在小菌落菌株中，无义等位基因lys1-1的突变率提高了3至6倍，错义等位基因his1-7的突变率提高了2倍。第三个等位基因，即假定的移码突变基因hom3-10，在小菌落背景下回复突变并未增强。结果表明，生物体的自发突变率可受细胞内间接影响而改变。
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