Obara Y
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
Hokkaido Igaku Zasshi. 1994 Sep;69(5):1132-9.
Herpes simplex virus (HSV) is well known for its propensity to cause recurrent oral or genital mucosal infections in humans. HSV-1 is involved primarily in oral lesions, whereas HSV-2 is more frequently involved in genital lesions. Based on this, it is thought that HSV-1 may produce latent infections in trigeminal ganglia, and HSV-2 in the sacral ganglia. However the distribution pattern of latent HSV-1 and HSV-2 infections in spinal ganglia remains unknown. Using the polymerase chain reaction we detected latent herpes HSV-1 and HSV-2 in human spinal ganglia obtained from autopsy material. A pair of primers which were specific for a part of the HSV-1 and HSV-2 DNA polymerase domain were employed. HSV-1 and HSV-2 DNAs were detected in 11 of 40 (28%) and 15 of 40 (38%) cervical ganglia, respectively, 52 of 103 (50%) and 47 of 103 (46%) thoracic ganglia, 16 of 53 (30%) and 17 of 53 (32%) lumbar ganglia, and 3 of 20 (15%) and 3 of 20 (15%) sacral ganglia. These findings suggest that latent HSV-1 and HSV-2 infections have a widespread distribution from the cervical ganglia to sacral ganglia. Importantly this study demonstrated latent HSV-1 infection of both the lumbar and sacral ganglia for the first time.
单纯疱疹病毒（HSV）因其易于在人类中引起复发性口腔或生殖器黏膜感染而广为人知。HSV - 1主要累及口腔病变，而HSV - 2更常累及生殖器病变。基于此，人们认为HSV - 1可能在三叉神经节产生潜伏感染，HSV - 2则在骶神经节产生潜伏感染。然而，HSV - 1和HSV - 2潜伏感染在脊髓神经节中的分布模式仍不清楚。我们使用聚合酶链反应在从尸检材料中获取的人类脊髓神经节中检测到潜伏的HSV - 1和HSV - 2。采用了一对针对HSV - 1和HSV - 2 DNA聚合酶结构域一部分的特异性引物。分别在40个颈神经节中的11个（28%）和40个中的15个（38%）检测到HSV - 1和HSV - 2 DNA，在103个胸神经节中的52个（50%）和103个中的47个（46%），在53个腰神经节中的16个（30%）和53个中的17个（32%），以及在20个骶神经节中的3个（15%）和20个中的3个（15%）检测到。这些发现表明，HSV - 1和HSV - 2潜伏感染从颈神经节到骶神经节广泛分布。重要的是，这项研究首次证明了腰神经节和骶神经节均存在HSV - 1潜伏感染。
