脂多糖诱导猪淋巴细胞在体内发生凋亡。
Lipopolysaccharide-induced apoptosis in swine lymphocytes in vivo.
作者信息
Norimatsu M, Ono T, Aoki A, Ohishi K, Takahashi T, Watanabe G, Taya K, Sasamoto S, Tamura Y
机构信息
National Veterinary Assay Laboratory, Tokyo, Japan.
出版信息
Infect Immun. 1995 Mar;63(3):1122-6. doi: 10.1128/iai.63.3.1122-1126.1995.
Abstract
The in vivo effects of bacterial lipopolysaccharide (LPS) on the immune systems of piglets were investigated. Intravenous injection of 0.5 mg of LPS per kilogram of body weight induced apoptosis, which was characterized by nuclear chromatin condensation and fragmentation and a ladder formation of nucleosomal DNA in lymphocytes both in the cortex of the thymus and in the germinal centers and paracortical areas of mesenteric lymph nodes at 24 h postinjection. The levels of endotoxin, tumor necrosis factor alpha, and cortisol in serum increased, generally according to the dose of LPS. These findings suggest that LPS can induce in vivo apoptosis of lymphocytes in piglets and support the notion that cytokine and endocrine responses may play an important role in LPS-induced apoptosis in the immune system.
摘要
研究了细菌脂多糖（LPS）对仔猪免疫系统的体内作用。静脉注射每千克体重0.5毫克LPS可诱导细胞凋亡，其特征为核染色质浓缩和碎片化，以及在注射后24小时胸腺皮质、肠系膜淋巴结生发中心和副皮质区的淋巴细胞中核小体DNA形成梯状条带。血清中内毒素、肿瘤坏死因子α和皮质醇水平一般随LPS剂量升高。这些发现表明LPS可在体内诱导仔猪淋巴细胞凋亡，并支持细胞因子和内分泌反应可能在LPS诱导的免疫系统细胞凋亡中起重要作用这一观点。
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