Effects of oil adjuvant on systemic response to Escherichia coli lipopolysaccharide in swine.
作者信息
Norimatsu M, Ogikubo Y, Kojima A, Takahashi T, Watanabe G, Taya K, Sasamoto S, Tamura Y
机构信息
National Veterinary Assay Laboratory, Kokubunji, Tokyo.
出版信息
J Vet Med Sci. 1995 Dec;57(6):1089-91. doi: 10.1292/jvms.57.1089.
PMID:8720054
Abstract
Intramuscular injection of 0.1 mg/kg of Escherichia coli lipopolysaccharide (LPS) mixed with Freund's complete adjuvant (LPS+FCA) in piglets mitigated the leukopenia and TNF-alpha and cortisol levels in the serum compared with that of LPS suspended in LPS-free saline. The endotoxin level in the serum of the LPS+FCA was remarkably reduced. These results suggest that the addition of oil adjuvant mitigate the systemic toxicity of LPS.
摘要
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