Hilgarth M
Fortschr Med. 1976 Sep 23;94(27):1485-7.
By using single-cell-DNS-cytophotometry in 28 single cases and 11 follow-up studies it was possible to differentiate the doubtful cytological findings and the mild and moderate dysplasia concerning the expected biological behaviour (risk of degeneration). If there are histograms similar to those with normal or inflammatory altered squamous epithelium, which are classified as "behaviour like a facultative precancerous lesion", further clinical observation is necessary. Histograms which show aneuploidy and/or wide spread to the right side are classified as "behaviour like an obligatory precancerous lesion". In these cases a conization should be performed, even if the findings are cytomorphological Pap III or mild dysplasias.
通过对28例单病例和11项随访研究采用单细胞DNA细胞光度测定法，就预期的生物学行为（退变风险）而言，能够鉴别可疑的细胞学发现以及轻度和中度发育异常。如果存在与正常或炎症改变的鳞状上皮相似的直方图，这些被归类为“行为类似兼性癌前病变”，则需要进一步的临床观察。显示非整倍体和/或广泛右移的直方图被归类为“行为类似 obligatory 癌前病变”。在这些情况下，即使检查结果为细胞形态学巴氏III级或轻度发育异常，也应进行锥形切除术。
