由鼠伤寒沙门氏菌制备的核糖体疫苗诱导的近交系小鼠保护作用的变异性。
Variability of protection in inbred mice induced by a ribosomal vaccine prepared from Salmonella typhimurium.
作者信息
Misfeldt M L, Johnson W
出版信息
Infect Immun. 1976 Sep;14(3):652-9. doi: 10.1128/iai.14.3.652-659.1976.
Abstract
Ribosomal vaccines prepared from Salmonella typhimurium were effective immunogens in A/J inbred mice and C3H/HeTex, inbred mice. However, ribosomal vaccines were not protective in C57BL/6J inbred mice. A/J mice were protected against lethal challenge by attenuated S. typhimurium live-cell, ribosomal, phenol, and heat-killed vaccines. C3H/HeTex mice were protected by live-cell, ribosomal, and phenol vaccines but not the heat-killed vaccine. Only the live-cell vaccine gave significant protection in the C57BL/6J inbred mice. A comparison of the kinetics of infection in sham-immunized mice and mice immunized with ribosomes showed that ribosome preparations elicited protection against Salmonella infection in mice inherently sensitive and resistant to Salmonella.
摘要
由鼠伤寒沙门氏菌制备的核糖体疫苗对A/J近交系小鼠和C3H/HeTex近交系小鼠是有效的免疫原。然而，核糖体疫苗对C57BL/6J近交系小鼠没有保护作用。A/J小鼠通过减毒活细胞、核糖体、苯酚和热灭活疫苗对致死性攻击具有保护作用。C3H/HeTex小鼠通过活细胞、核糖体和苯酚疫苗得到保护，但热灭活疫苗则无保护作用。只有活细胞疫苗对C57BL/6J近交系小鼠有显著保护作用。对假免疫小鼠和用核糖体免疫的小鼠感染动力学的比较表明，核糖体制剂能诱导对沙门氏菌感染具有固有敏感性和抗性的小鼠产生针对沙门氏菌感染的保护作用。
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