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A sequential approach to testing with the rodent bone marrow micronucleus assay--obviation of the need for statistical analyses of data.

作者信息

Ashby J, Tinwell H

机构信息

Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK.

出版信息

Mutat Res. 1995 Mar;327(1-2):49-55. doi: 10.1016/0027-5107(95)93252-m.

DOI:10.1016/0027-5107(95)93252-m
PMID:7870097
Abstract

The 'sequential' protocol we use for the conduct of mouse bone marrow micronucleus assays is described. The most important criterion for activity in the assay is the reproducibility of any induced effects. The frequencies of micronucleated polychromatic erythrocytes among 239 male CBA control mice are displayed and discussed. Our decision to avoid statistical analysis when assessing mouse bone marrow micronucleus data is explained.

摘要

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