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苯丁酸氮芥对小鼠骨髓的致断裂性：在某些试验中与其作用的遗传特异性相关的考量

Clastogenicity of chlorambucil to the mouse bone marrow: consideration in relation to its genetic specificity of action in some assays.

作者信息

Ashby J, Tinwell H

机构信息

ZENECA Central Toxicology Laboratory, Macclesfield, Cheshire, UK.

出版信息

Mutagenesis. 1993 Jul;8(4):373-5. doi: 10.1093/mutage/8.4.373.

DOI:10.1093/mutage/8.4.373
PMID:8377658
Abstract

The human carcinogen and mouse germ cell mutagen chlorambucil is reported here to give a strong positive response in the mouse bone marrow micronucleus assay (4 mg/kg; single intraperitoneal injection). An increased incidence of micronucleated bone marrow white cells was also observed. It is concluded that chlorambucil is a broad spectrum mutagen that possesses subtle and specific mutagenic activities in some assay systems.

摘要

据报道，人类致癌物及小鼠生殖细胞诱变剂苯丁酸氮芥在小鼠骨髓微核试验中产生强烈阳性反应（4毫克/千克；单次腹腔注射）。还观察到骨髓白细胞微核发生率增加。结论是苯丁酸氮芥是一种广谱诱变剂，在某些检测系统中具有微妙而特定的诱变活性。

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