MacFall J R, Byrum C E, Parashos I, Early B, Charles H C, Chittilla V, Boyko O B, Upchurch L, Krishnan K R
Department of Radiology, Duke University Medical Center, Durham, NC 27710.
Psychiatry Res. 1994 Sep;55(3):167-77. doi: 10.1016/0925-4927(94)90024-8.
Volumetric magnetic resonance imaging (MRI) methods for the measurement of various neuroanatomical regions are of great interest in studies of neuropsychiatric disorders. Both manual and semiautomated methods have been developed. Manual methods include tracing and point counting. Point counting methods are widely used in post-mortem and microscopy studies. Point counting has been well validated for these purposes. In this article, we report in a series of separate studies the accuracy and reproducibility of point-counting methods. Absolute accuracy was evaluated with a spherical phantom. Accuracy and time efficiency were subsequently assessed with an anatomically realistic phantom and various size grids. The point-counting method was also compared to a tracing method. Finally, the reproducibility of the point-counting method for the caudate and putamen was evaluated on four subjects in a test-retest experiment. These studies provide an estimate of the accuracy and time efficiency of point-counting methods. The test-retest reliability was also high for both caudate and putamen. Findings suggest that point counting is a reliable and efficient method for estimating volumes.
用于测量各种神经解剖区域的容积磁共振成像（MRI）方法在神经精神疾病研究中备受关注。手动和半自动方法都已得到开发。手动方法包括追踪和点数。点数方法广泛应用于尸检和显微镜研究。点数方法已针对这些目的得到充分验证。在本文中，我们在一系列单独的研究中报告了点数方法的准确性和可重复性。使用球形模型评估绝对准确性。随后使用解剖学逼真的模型和各种尺寸的网格评估准确性和时间效率。还将点数方法与追踪方法进行了比较。最后，在一项重测实验中对四名受试者评估了尾状核和壳核点数方法的可重复性。这些研究提供了点数方法准确性和时间效率的估计值。尾状核和壳核的重测信度也很高。研究结果表明，点数是一种可靠且高效的估计体积的方法。
