McCance-Katz E F, Price L H, McDougle C J, Kosten T R, Black J E, Jatlow P I
Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven 06508.
Psychopharmacology (Berl). 1993;111(1):39-46. doi: 10.1007/BF02257405.
Simultaneous abuse of cocaine and ethanol is a common occurrence. Cocaethylene, the ethyl ester of benzoylecgonine, has been detected in the urine of patients reporting concurrent use of cocaine and ethanol, and high levels have been found in the blood of victims of fatal drug overdose. This placebo-controlled, double-blind study examined the pharmacokinetic, physiologic, and behavioral effects of dual cocaine and ethanol administration in humans (n = 6). Cocaethylene was found in the plasma only after administration of both cocaine and ethanol, and appeared to be eliminated more slowly than cocaine. Plasma cocaine concentrations were significantly higher during cocaine/ethanol administration. Euphorigenic effects were both enhanced and prolonged, and heart rate was significantly increased, following cocaine/ethanol administration as compared to administration of cocaine or ethanol alone.
可卡因和乙醇同时滥用的情况很常见。在报告同时使用可卡因和乙醇的患者尿液中检测到了苯甲酰芽子碱的乙酯——可口卡因，并且在致命药物过量受害者的血液中发现了高浓度的可口卡因。这项安慰剂对照、双盲研究考察了可卡因和乙醇联合给药对人体（n = 6）的药代动力学、生理学和行为学影响。仅在同时给予可卡因和乙醇后，血浆中才检测到可口卡因，而且其消除速度似乎比可卡因更慢。在可卡因/乙醇联合给药期间，血浆可卡因浓度显著更高。与单独给予可卡因或乙醇相比，可卡因/乙醇联合给药后，欣快效应增强且持续时间延长，心率显著增加。
