Idzior-Waluś B, Solnica B, Szopinska-Ciba L, Sieradzki J
Kliniki Chorób Metabolicznych Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków.
Przegl Lek. 1994;51(11):468-74.
Cardiovascular complications are the main cause of disability and deaths in insulin dependent diabetic patients. The main aim of the EURODIAB IDDM Complications Study was to assess the prevalence of diabetes complications and of risk factors of these complications. In this study the data on cardiovascular diseases and their risk factors in patients included in the EURODIAB IDDM Complications Study--Krakow are presented. The study population included insulin dependent clinic attenders, aged 15-60 years, diagnosed before the age of 36 years. A random sample of up to 140 patients stratified by age, sex and duration of diabetes was chosen. Within each centre the study population consisted of all eligible IDDM patients living in a defined catchement area, who had attended the center at least once during the preceding 12 months. The studied sample included 120 patients (61 men and 59 women). Mean (sd) age of patients was 34.0 (9.6) years, mean duration of diabetes 14.2 (9.8) years, mean Hb A1c concentration 6.6 (1.5)%. The prevalence of cardiovascular diseases was assessed using standardized questionnaire and resting electrocardiogram. Blood pressure was measured with "random zero" sphygmomanometer. Electrocardiogram was assessed according to Minnesota code. Serum cholesterol and triglyceride concentration were determined by enzymatic methods. Albumin excretion rate was determined in 24 hours urine collection. Albumin concentration was assayed by immunoturbidimetry. Cardiovascular diseases were observed in 8.3% of patients. Arterial hypertension (WHO dfn) was found in 11.7% of patients, systolic blood pressure > or = 140 mm Hg in 9.2% of patients and diastolic blood pressure > or = 90 mm Hg in about 5% of men and 2% of women. Hypercholesterolemia (serum cholesterol > or = 6.5 mmol/l) was found in about 20% of patients, hypertriglyceridemia (serum triglyceride 2.2 mmol/1) in 16.4% of men and 10.2% of women. 41.0% of men and 28.8% of women were current cigarette smokers. Microalbuminuria (defined as albumin excretion rate 20-200 micrograms/min) was observed in 23% of men and 15.3% of women.(ABSTRACT TRUNCATED AT 250 WORDS)
心血管并发症是胰岛素依赖型糖尿病患者致残和死亡的主要原因。欧洲糖尿病研究（EURODIAB IDDM Complications Study）的主要目的是评估糖尿病并发症及其危险因素的患病率。本文呈现了欧洲糖尿病研究——克拉科夫（EURODIAB IDDM Complications Study--Krakow）中患者心血管疾病及其危险因素的数据。研究人群包括年龄在15至60岁、36岁之前确诊的胰岛素依赖型门诊患者。选取了一个按年龄、性别和糖尿病病程分层的多达140名患者的随机样本。在每个中心，研究人群由居住在特定服务区域内、在过去12个月中至少到该中心就诊过一次的所有符合条件的胰岛素依赖型糖尿病患者组成。研究样本包括120名患者（61名男性和59名女性）。患者的平均（标准差）年龄为34.0（9.6）岁，糖尿病平均病程为14.2（9.8）年，平均糖化血红蛋白（Hb A1c）浓度为6.6（1.5）%。使用标准化问卷和静息心电图评估心血管疾病的患病率。用“随机零点”血压计测量血压。根据明尼苏达编码评估心电图。采用酶法测定血清胆固醇和甘油三酯浓度。通过收集24小时尿液测定白蛋白排泄率。用免疫比浊法测定白蛋白浓度。8.3%的患者观察到心血管疾病。11.7%的患者发现动脉高血压（世界卫生组织定义），9.2%的患者收缩压≥140毫米汞柱，约5%的男性和2%的女性舒张压≥90毫米汞柱。约20%的患者发现高胆固醇血症（血清胆固醇≥6.5毫摩尔/升），16.4%的男性和10.2%的女性发现高甘油三酯血症（血清甘油三酯≥2.2毫摩尔/升）。41.0%的男性和28.8%的女性为当前吸烟者。23%的男性和15.3%的女性观察到微量白蛋白尿（定义为白蛋白排泄率20 - 200微克/分钟）。（摘要截选至250词）
