[胰岛素依赖型糖尿病患者血清中的脂质紊乱。欧洲糖尿病研究协会糖尿病并发症研究——克拉科夫]
[Lipid disorders in serum of patients with insulin dependent diabetes mellitus. EURODIAB IDDM Complications Study--Kraków].
作者信息
Idzior-Walus B, Solnica B, Sieradzki J, Szopińska-ciba L
机构信息
Kliniki Chorób Metabolicznych Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland.
出版信息
Pol Tyg Lek. 1996 Jan;51(1-5):7-10.
The aim of this study was to assess the prevalence of the lipid metabolism disorders and their determinants in a group of patients with insulin dependent diabetes mellitus, included in the EURODIAB IDDM Complications Study in Kraków center. We examined 120 patients with insulin dependent diabetes mellitus. Hypercholesterolemia (serum cholesterol > 5,2 mmol/l) was observed in 61,7% of patients, hypertriglyceridemia (serum triglycerides > 1,7 mmol/l) in 20,8% of patients, hypo-HDL-cholesterolemia (HDL-cholesterol 0,9 mmol/l) in 4,2% of patients. The mean values of total and LDL-cholesterol concentrations increased and mean HDL and HDL3-cholesterol concentration decreased from I to III tertile of HbAlc concentration. The results of this study indicate the high prevalence of hyperlipidemia and need of monitoring serum lipid concentration in IDDM patients.
本研究的目的是评估一组纳入克拉科夫中心欧洲糖尿病研究（EURODIAB IDDM Complications Study）的胰岛素依赖型糖尿病患者脂质代谢紊乱的患病率及其决定因素。我们检查了120例胰岛素依赖型糖尿病患者。61.7%的患者出现高胆固醇血症（血清胆固醇>5.2 mmol/L），20.8%的患者出现高甘油三酯血症（血清甘油三酯>1.7 mmol/L），4.2%的患者出现低高密度脂蛋白胆固醇血症（高密度脂蛋白胆固醇<0.9 mmol/L）。从糖化血红蛋白（HbAlc）浓度的第一三分位数到第三三分位数，总胆固醇和低密度脂蛋白胆固醇浓度的平均值升高，而高密度脂蛋白和高密度脂蛋白3胆固醇浓度的平均值降低。本研究结果表明高脂血症在胰岛素依赖型糖尿病患者中患病率很高，且需要监测其血清脂质浓度。
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