Nakatsuka M, Yoshida N, Hasegawa A, Nishikori K, Hirano Y, Katayama T, Shintani K, Noma J, Shimizu K, Kudo T
Department of Obstetrics and Gynecology, Okayama University Medical School.
Nihon Sanka Fujinka Gakkai Zasshi. 1993 May;45(5):431-6.
The efficacy of examining antinuclear antibody (ANA) was investigated as a screening test detecting subclinical immune disorders in infertility and sterility. ANA was measured in 116 unexplained infertile or sterile patients. The ANA positive rate was 43.5% in group A (habitual abortion, n = 23), 38.1% in group B (consecutive miscarriages, n = 21), 30.0% in group C (one miscarriage, n = 10), 16.7% in group D (one or more deliveries n = 12) 22.0% in group E (primary sterility, n = 50), and 22.4% in the control group (n = 54). The positive rate for all the infertile patients (group A+B) was 40.9% and significantly higher than that in for the control group (p < 0.05). Ten patients with positive ANA had 12 deliveries and 20 patients with negative ANA had 23 deliveries. The frequency of preeclampsia in the patients with positive ANA was higher than in those with negative ANA (41.7% versus 4.3%, p < 0.05). A higher incidence of premature deliveries was recognized in the patients with positive ANA than in those with negative ANA (41.7% versus 8.7%, p < 0.1). Average birth weight (> 35 week) for patients with and without positive ANA was 2,976g (n = 8) and 3,122g (n = 19) respectively. The former tends to be smaller than the latter (p < 0.1).
研究抗核抗体（ANA）检测作为筛查不孕不育症亚临床免疫紊乱的有效性。对116例不明原因的不孕或不育患者进行了ANA检测。A组（习惯性流产，n = 23）的ANA阳性率为43.5%，B组（连续流产，n = 21）为38.1%，C组（一次流产，n = 10）为30.0%，D组（一次或多次分娩，n = 12）为16.7%，E组（原发性不育，n = 50）为22.0%，对照组（n = 54）为22.4%。所有不孕患者（A组+B组）的阳性率为40.9%，显著高于对照组（p < 0.05）。ANA阳性的10例患者分娩12次，ANA阴性的20例患者分娩23次。ANA阳性患者的先兆子痫发生率高于ANA阴性患者（41.7%对4.3%，p < 0.05）。ANA阳性患者的早产发生率高于ANA阴性患者（41.7%对8.7%，p < 0.1）。ANA阳性和阴性患者的平均出生体重（> 35周）分别为2976g（n = 8）和3122g（n = 19）。前者往往低于后者（p < 0.1）。
