Comings D E
Department of Medical Genetics, City of Hope National Medical Center, Duarte, California 91010.
Adv Neurol. 1995;65:293-303.
Tourette's syndrome is a fascinating, complex, hereditary, neuropsychiatric spectrum disorder in which the tics are only one of many symptoms. Data to date suggest the mechanism of inheritance is just as complex as the disorder itself and involves the coming together of a number of common genes that affect dopamine and serotonin metabolism. Because these neurotransmitters modulate the function of many areas of the brain, the result is a wide spectrum of behavioral disorders. As such TS provides a significant challenge to the physician. Because many of the newer medications are quite effective, taking on the treatment of this challenging and complex behavioral spectrum disorder can be extremely rewarding.
图雷特综合征是一种引人入胜、复杂的遗传性神经精神谱系障碍，其中抽动只是众多症状之一。迄今为止的数据表明，其遗传机制与该疾病本身一样复杂，涉及多个影响多巴胺和血清素代谢的常见基因共同作用。由于这些神经递质调节大脑许多区域的功能，结果导致了广泛的行为障碍。因此，图雷特综合征给医生带来了重大挑战。由于许多新型药物相当有效，治疗这种具有挑战性和复杂性的行为谱系障碍可能会带来极大的回报。
