Jin R, Kurashige S
Department of Medical Technology, College of Medical Care and Technology, Gunma University, Japan.
Immunopharmacol Immunotoxicol. 1996 Feb;18(1):105-14. doi: 10.3109/08923979609007113.
We investigated the effect of Chinese herbs Lithospermi radix, Astragali radix and Cnidii rhizoma on the functions of macrophages obtained from mice treated with the carcinogen N-butyl-N-butanolnitrosoamine (BBN). The chemotactic activity of murine macrophages was significantly decreased by 17 weeks of treatment with BBN compared with controls. Production of IL-1 and TNF was also markedly reduced. Treatment with Lithospermi radix, Astragali radix, and Cnidii rhizoma significantly inhibited BBN-induced suppression chemotactic activity and production of IL-1 and TNF-alpha by macrophages. Moreover, we found that Astragali radix treated macrophage chemotaxis, it or Cnidii rhizoma induced productions of TNF-alpha were in excess of control.
我们研究了中药紫草、黄芪和蛇床子对用致癌物N-丁基-N-丁醇亚硝胺（BBN）处理的小鼠巨噬细胞功能的影响。与对照组相比，BBN处理17周后，小鼠巨噬细胞的趋化活性显著降低。白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）的产生也明显减少。紫草、黄芪和蛇床子处理可显著抑制BBN诱导的巨噬细胞趋化活性抑制以及IL-1和肿瘤坏死因子-α（TNF-α）的产生。此外，我们发现黄芪处理巨噬细胞趋化性，其本身或蛇床子诱导的TNF-α产生量超过对照组。
