Jin R, Wan L L, Mitsuishi T, Kodama K, Kurashige S
Department of Microbiology, School of Medicine, Maebashi, Japan.
Yakugaku Zasshi. 1994 Jul;114(7):533-8. doi: 10.1248/yakushi1947.114.7_533.
Extracts of Chinese herbs were administered with antitumor agent, cyclophosphamide (CY), and their effects on macrophages and lymphocytes were studied. Number of peritoneal macrophages significantly decreased and their chemotactic activity was suppressed by treatment with CY. Blastogenic responsiveness to Concanavalin A and NK cell activity of spleen lymphocytes were suppressed significantly in CY-treated mice. Extracts of Lithospermi radix, Astragali radix and Glycyrrhizae radix showed protective effects on immunosuppressive mice. The number of macrophages, chemotactic activity of macrophages and blastogenic response of lymphocytes were recovered to the same or more than that of normal levels. An extract of Ginseng radix showed protective effects on the number and functions of macrophages by treatment with CY but did not show any effects on the lymphocytic blastogenesis. On the contrary it showed a strong inhibitory effect on the NK cell activity. These results suggest that Chinese herbs could modulate cellular immune response, especially in the activation of macrophages and splenic lymphocytes.
将中药提取物与抗肿瘤药物环磷酰胺（CY）联合使用，并研究它们对巨噬细胞和淋巴细胞的影响。用CY处理后，腹腔巨噬细胞数量显著减少，其趋化活性受到抑制。在经CY处理的小鼠中，脾淋巴细胞对刀豆球蛋白A的增殖反应性和NK细胞活性均受到显著抑制。紫草、黄芪和甘草的提取物对免疫抑制小鼠具有保护作用。巨噬细胞数量、巨噬细胞趋化活性和淋巴细胞增殖反应恢复到正常水平或高于正常水平。人参提取物对经CY处理的巨噬细胞数量和功能具有保护作用，但对淋巴细胞增殖没有任何影响。相反，它对NK细胞活性表现出强烈的抑制作用。这些结果表明，中药可以调节细胞免疫反应，特别是在激活巨噬细胞和脾淋巴细胞方面。
