Jonas J B, Papastathopoulos K I
Department of Ophthalmology, University Erlangen-Nürnberg, Germany.
Am J Ophthalmol. 1995 Mar;119(3):313-7. doi: 10.1016/s0002-9394(14)71173-0.
This study was performed to differentiate glaucomatous changes of the optic disk that may be caused by increased intraocular pressure from those that may be pressure independent.
For 357 patients with primary open-angle glaucoma, the optic disk was morphometrically analyzed, and the intraocular pressure was measured in 24-hour profiles.
By performing an intraindividual bilateral comparison, the differences in the maximal intraocular pressure values of the right eye minus the left eye of the same individual were significantly correlated with the differences in neuroretinal rim area and mean perimetric defect of the right eye minus the left eye. No significant correlations were found for the parapapillary atrophy.
The results indicate that the eye with the higher pressure compared with the fellow eye with the lower pressure showed neither a significantly larger nor smaller parapapillary atrophy, which suggests that the papapapillary atrophy, compared with the neuroretinal rim area and the visual field defect, is less dependent or almost independent of an increased intraocular pressure.
本研究旨在区分可能由眼内压升高引起的视盘青光眼性改变与那些可能与压力无关的改变。
对357例原发性开角型青光眼患者的视盘进行形态计量分析，并测量24小时眼压曲线。
通过个体双侧比较，同一个体右眼与左眼最大眼压值的差异与右眼与左眼神经视网膜边缘面积及平均视野缺损的差异显著相关。视盘周围萎缩无显著相关性。
结果表明，与眼压较低的对侧眼相比，眼压较高的眼视盘周围萎缩既没有明显增大也没有明显减小，这表明与神经视网膜边缘面积和视野缺损相比，视盘周围萎缩较少依赖或几乎不依赖于眼压升高。
