Eledjam J J
Département d'Anesthésie-Réanimation, Centre Hospitalier Universitaire, Nîmes.
Ann Fr Anesth Reanim. 1994;13(4):593-7. doi: 10.1016/s0750-7658(05)80706-3.
During regional anaesthesia, sedation can be used to obviate any discomfort which is unrelated to a technical insufficiency of the block or a particular anxiety of the patient. Sedation increases the acceptability of the technique by the patient. The main characteristics of propofol are its short onset time of action, and the rapid reversibility of its effects after the end of its administration. For induction of anaesthesia, propofol is given as a bolus injection, an average dose being 10 to 20 mg. Maintenance is best achieved with a continuous infusion, at a rate of 3 to 4 mg.kg-1.h-1. Titration of propofol allows the ideal stage of sedation to be reached (MacKenzie Grade 3), followed by a fast recovery. Close monitoring of the patient is mandatory and should include clinical supervision and pulse oximetry in all cases.
在区域麻醉期间，可使用镇静来消除与阻滞技术不足或患者特定焦虑无关的任何不适。镇静可提高患者对该技术的接受度。丙泊酚的主要特点是起效时间短，给药结束后作用迅速可逆。用于麻醉诱导时，丙泊酚以单次静脉注射给药，平均剂量为10至20毫克。维持麻醉最佳采用持续输注，速率为3至4毫克·千克⁻¹·小时⁻¹。滴定丙泊酚可达到理想的镇静阶段（麦肯齐3级），随后快速恢复。必须对患者进行密切监测，所有病例均应包括临床监护和脉搏血氧饱和度监测。
