Valero G, Moreno F, Graybill J R
Department of Infectious Diseases, Audie L. Murphy Memorial Veterans Hospital, San Antonio, TX 78284.
Antimicrob Agents Chemother. 1994 Nov;38(11):2676-7. doi: 10.1128/AAC.38.11.2676.
After 2 weeks of intravenous challenge with Mycobacterium simiae, ICR outbred mice were treated with clarithromycin, ofloxacin, or clarithromycin plus ethambutol for 4 weeks. All three therapy groups demonstrated a decrease in the level of infection in both the lungs and the spleen. There were no significant differences among the three treated groups in decreasing mycobacterial counts in the lungs; however, both ofloxacin and clarithromycin plus ethambutol were superior to clarithromycin alone in reducing the level of infection in the spleen. Results of the study suggest a potential role for these agents in the treatment of human M. simiae infection.
在用猿分枝杆菌进行2周静脉内攻击后，对ICR远交系小鼠用克拉霉素、氧氟沙星或克拉霉素加乙胺丁醇治疗4周。所有三个治疗组在肺和脾中的感染水平均有所下降。三个治疗组在降低肺部分枝杆菌数量方面没有显著差异；然而，氧氟沙星和克拉霉素加乙胺丁醇在降低脾脏感染水平方面均优于单独使用克拉霉素。该研究结果表明这些药物在治疗人类猿分枝杆菌感染中可能发挥作用。
