Huminer D, Dux S, Samra Z, Kaufman L, Lavy A, Block C S, Pitlik S D
Department of Internal Medicine C, Beilinson Medical Center, Petach Tikvah, Israel.
Clin Infect Dis. 1993 Sep;17(3):508-9. doi: 10.1093/clinids/17.3.508.
Mycobacterium simiae is an environmental organism that has rarely been associated with human disease. In Israel M. simiae is frequently isolated from clinical specimens, and it usually colonizes damaged lungs. Until now, only two cases of AIDS patients with M. simiae infection have been reported, and these patients were coinfected with Mycobacterium avium complex. Two Israeli patients with AIDS complicating hemophilia developed prolonged fever that was unresponsive to therapy with broad-spectrum antibiotics. One of them had cavitary pulmonary infiltrates. M. simiae was isolated from blood in both cases and from sputum and bone marrow in one case. The identity of the mycobacterium was confirmed at three reference laboratories. Both patients died of the infection. Thus, the possibility of M. simiae infection should be considered for AIDS patients who live in areas where this mycobacterium is prevalent.
猿猴分枝杆菌是一种环境微生物，很少与人类疾病相关。在以色列，猿猴分枝杆菌经常从临床标本中分离出来，并且通常定植于受损的肺部。到目前为止，仅报道了两例艾滋病患者感染猿猴分枝杆菌的病例，这些患者同时感染了鸟分枝杆菌复合群。两名患有艾滋病并发血友病的以色列患者出现持续发热，对广谱抗生素治疗无反应。其中一人有肺空洞浸润。在两例患者的血液中均分离出猿猴分枝杆菌，在一例患者的痰液和骨髓中也分离出该菌。三个参考实验室确认了分枝杆菌的身份。两名患者均死于感染。因此，对于生活在这种分枝杆菌流行地区的艾滋病患者，应考虑猿猴分枝杆菌感染的可能性。
