Ramos Fernández J, Avilés Mañoso P, Martín Atienza R, Lozano Barriuso M A, Fernández-Vega M
Servicio de ORL, Hospital General Gregorio Marañón, Universidad Complutense, Madrid.
Acta Otorrinolaringol Esp. 1994 Nov-Dec;45(6):451-6.
We present a retrospective study of 49 cases of squamous cell carcinoma of the pyriform sinus treated with induction chemotherapy (group I) and compared with 103 cases that did not received this treatment (group II). Thirty four patients were treated with combined cis-platinum and 5-fluoracil. Local and regional control and distant metastasis were analyzed, and no differences between the two groups were found. Five-year global actuarial survival rates were 23% in group I, and 35% in group II (p = no significant). In group I, those cases that responded to chemotherapy had a better 4-year survival rate (33%) than those who did not (7%) (p < 0.1). When patients who underwent radical radiotherapy were analyzed, a better 5-year survival rate was found in group I (41%) versus group II (13%) (p < 0.05).
我们对49例接受诱导化疗的梨状窦鳞状细胞癌患者进行了回顾性研究（第一组），并与103例未接受该治疗的患者（第二组）进行比较。34例患者接受了顺铂和5-氟尿嘧啶联合治疗。分析了局部和区域控制以及远处转移情况，发现两组之间无差异。第一组的5年总精算生存率为23%，第二组为35%（p =无显著性差异）。在第一组中，对化疗有反应的患者4年生存率（33%）高于无反应者（7%）（p < 0.1）。对接受根治性放疗的患者进行分析时，发现第一组的5年生存率（41%）优于第二组（13%）（p < 0.05）。
