Sung R J
Cardiac Electrophysiology and Arrhythmia Service, Stanford University Medical Center, California.
Cardiovasc Drugs Ther. 1994 Oct;8(5):773-4. doi: 10.1007/BF00877126.
Although amiodarone is the most effective antiarrhythmic agent for maintaining sinus rhythm in patients with atrial fibrillation, it is generally used as the drug of the last resort in the United States. This is because long-term amiodarone therapy can potentially cause serious noncardiac side effects, such as pulmonary fibrosis, thyroid dysfunction, hepatitis, and neurotoxicity. Furthermore, it may also cause adverse interaction with digoxin, coumadin, and other antiarrhythmic drugs. Atrial fibrillation is frequently associated with a variety of cardiac disease, and its triggering factors vary among patients. Treatment strategy should be tailored to each individual patient according to the clinical presentation, concomitant disease, left ventricular function, and response (efficacy and side effects) to each drug regimen.
虽然胺碘酮是维持心房颤动患者窦性心律最有效的抗心律失常药物，但在美国它通常被用作最后手段的药物。这是因为长期胺碘酮治疗可能会导致严重的非心脏副作用，如肺纤维化、甲状腺功能障碍、肝炎和神经毒性。此外，它还可能与地高辛、华法林和其他抗心律失常药物发生不良相互作用。心房颤动常与多种心脏疾病相关，其触发因素在患者之间各不相同。治疗策略应根据每个患者的临床表现、伴随疾病、左心室功能以及对每种药物治疗方案的反应（疗效和副作用）进行个体化调整。
