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Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.

作者信息

Kaushik N, Stoye J P

机构信息

National Institute for Medical Research, London, UK.

出版信息

Mamm Genome. 1994 Nov;5(11):688-95. doi: 10.1007/BF00426074.

DOI:10.1007/BF00426074
PMID:7873878
Abstract

We describe a novel, PCR-based technique termed REVEAL-PCR for examining the inheritance of intracisternal A-type particles (IAP). Amplifications use an unlabeled primer to SINE repeats and a radiolabeled primer to the IAP long terminal repeat; labeled products, which can be resolved on sequencing gels, are formed when IAPs lie in proximity to SINEs. With this technique we have identified a total of 124 polymorphisms in the BXH and CXS recombinant inbred strains. We suggest that this method will be equally applicable for examining other gene families present at around a thousand copies per genome.

摘要

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本文引用的文献

1
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2
The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.MEV小鼠连锁测试品系：定位30个新的前病毒插入位点并建立改良品系。
Genomics. 1993 May;16(2):380-94. doi: 10.1006/geno.1993.1201.
3
Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes.
Gv1基因的遗传分析，该基因控制内源性鼠多嗜性前病毒的转录。
J Virol. 1999 Oct;73(10):8227-34. doi: 10.1128/JVI.73.10.8227-8234.1999.
4
New seizure frequency QTL and the complex genetics of epilepsy in EL mice.EL小鼠中新的癫痫发作频率数量性状基因座与癫痫的复杂遗传学
Mamm Genome. 1995 Dec;6(12):830-8. doi: 10.1007/BF00292431.
5
The stumbler mutation maps to proximal mouse chromosome 2.
Mamm Genome. 1994 Nov;5(11):659-62. doi: 10.1007/BF00426071.
6
Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse chromosome 4.小鼠4号染色体上逆转录病毒限制位点Fv1周围区域的遗传图谱。
Mamm Genome. 1995 Jan;6(1):31-6. doi: 10.1007/BF00350890.
B6C3F1小鼠丁二烯诱导的肺癌和乳腺癌的等位基因分型：与人类肿瘤抑制基因同源区域杂合性的频繁缺失
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3759-63. doi: 10.1073/pnas.91.9.3759.
4
Structure and expression of the hairless gene of mice.小鼠无毛基因的结构与表达
Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7717-21. doi: 10.1073/pnas.91.16.7717.
5
Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.lpr小鼠Fas抗原基因内含子中早期转座元件插入导致的异常转录。
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1756-60. doi: 10.1073/pnas.90.5.1756.
6
Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs.在小鼠稀释毛色回复突变体中，DBA嗜亲性前病毒的切除是通过涉及病毒长末端重复序列（LTRs）的同源重组发生的。
Cell. 1983 Jun;33(2):379-87. doi: 10.1016/0092-8674(83)90419-1.
7
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Nucleic Acids Res. 1982 Dec 11;10(23):7461-75. doi: 10.1093/nar/10.23.7461.
8
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Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.DBA/2J小鼠的稀释（d）毛色突变与嗜亲性小鼠白血病病毒（MuLV）基因组的整合位点有关。
Nature. 1981 Oct 1;293(5831):370-4. doi: 10.1038/293370a0.
10
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Proc Natl Acad Sci U S A. 1980 Oct;77(10):5774-8. doi: 10.1073/pnas.77.10.5774.