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The stumbler mutation maps to proximal mouse chromosome 2.

作者信息

Frankel W N, Sweet H O, Davisson M T

机构信息

Jackson Laboratory, Bar Harbor, Maine 04609.

出版信息

Mamm Genome. 1994 Nov;5(11):659-62. doi: 10.1007/BF00426071.

DOI:10.1007/BF00426071
PMID:7873875
Abstract

The cerebellar mouse mutation stumbler (stu) was mapped to proximal Chromosome (Chr) 2 with a recently developed polymerase chain reaction assay for endogenous retroviruses that vary between mouse strains. The stu locus resides between the markers D2Mit5 and D2Mit7. A number of developmentally or neurologically relevant candidate genes map in this region, including Bmi1, Dbh, Grin1, Notch1, Pax8, Rxra, and Spna2. Knowing the chromosomal localization of stu should simplify maintenance of the stumbler mouse stock and also enable analysis of the cerebellar defect in presymptomatic individuals.

摘要

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本文引用的文献

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2
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Mamm Genome. 1993;4(2):78-82. doi: 10.1007/BF00290430.
3
Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively.
EL小鼠中新的癫痫发作频率数量性状基因座与癫痫的复杂遗传学
Mamm Genome. 1995 Dec;6(12):830-8. doi: 10.1007/BF00292431.
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Genome maps IV 1993. Wall chart.基因组图谱IV 1993。挂图。
Science. 1993 Oct 1;262(5130):67-82. doi: 10.1126/science.8211131.
5
Identification and genetic mapping of the murine gene and 20 related sequences encoding chromosomal protein HMG-17.
Mamm Genome. 1993;4(2):83-9. doi: 10.1007/BF00290431.
6
Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.来自两个种间回交DNA面板的图谱可作为社区遗传图谱资源使用。
Mamm Genome. 1994 May;5(5):253-74. doi: 10.1007/BF00389540.
7
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.
Genes Dev. 1994 Apr 1;8(7):757-69. doi: 10.1101/gad.8.7.757.
8
Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.
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10
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Brain Res. 1981 Apr;227(2):221-36. doi: 10.1016/0165-3806(81)90110-3.