Lutfy K, Sadowski B, Kwon I S, Weber E
Department of Pharmacology, School of Medicine, University of California, Irvine 92717.
Eur J Pharmacol. 1994 Nov 24;265(3):171-4. doi: 10.1016/0014-2999(94)90428-6.
Morphine-induced analgesia and tolerance were examined in Swiss Webster mice selectively bred for high and low swim stress-induced analgesia. Morphine produced a dose-dependent analgesia in both lines; it was 4-fold more potent in the high analgesia line than in the low analgesia line. Despite the differences in morphine-induced analgesia, the degree of tolerance was the same in both lines. Together, these data suggest that selective breeding of mice for high and low swim stress-induced analgesia produced a striking difference in morphine-induced analgesia without affecting the degree of tolerance. Thus, while there is a common genetic determination in swim stress-induced and morphine-induced analgesia, the development of tolerance to morphine possibly relies on a different genetic background.
在因高、低游泳应激诱导镇痛而进行选择性培育的瑞士韦伯斯特小鼠中，检测了吗啡诱导的镇痛作用和耐受性。吗啡在两个品系中均产生剂量依赖性镇痛作用；在高镇痛品系中其效力比低镇痛品系高4倍。尽管吗啡诱导的镇痛作用存在差异，但两个品系的耐受程度相同。这些数据共同表明，对小鼠进行高、低游泳应激诱导镇痛的选择性培育，在吗啡诱导的镇痛作用方面产生了显著差异，而不影响耐受程度。因此，虽然游泳应激诱导的镇痛和吗啡诱导的镇痛存在共同的遗传决定因素，但对吗啡耐受性的产生可能依赖于不同的遗传背景。
