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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Kim N D, Kang S Y, Schini V B

College of Pharmacy, Seoul National University, Korea.

Gen Pharmacol. 1994 Oct;25(6):1071-7. doi: 10.1016/0306-3623(94)90121-x.

Ginsenoside (10-100 mg/kg, i.v.) lowered blood pressure in a dose-dependent manner in rats. 2. Ginsenoside (10(-5)-3 x 10(-4) g/ml) relaxed the aorta after contractions were induced by 10(-6) M phenylephrine in the aorta with endothelium but not in that without endothelium. 3. The relaxation induced by ginsenoside was attenuated by 3 x 10(-7) M methylene blue (MB) and 10(-4) M NG-monomethyl-L-arginine (L-NMMA) but not inhibited by 10(-5) M indomethacin. 4. Ginsenoside (10(-4) g/ml for 2 min) increased the accumulation of cGMP in rings with endothelium. L-NMMA and MB inhibited the accumulation of cGMP induced by ginsenoside. 5. These data suggest that vascular relaxations induced by ginsenoside are mediated by release of endothelium-drived nitric oxide which enhances the accumulation of cGMP.

人参皂苷（10 - 100毫克/千克，静脉注射）以剂量依赖方式降低大鼠血压。2. 人参皂苷（10⁻⁵ - 3×10⁻⁴克/毫升）在由10⁻⁶ M去氧肾上腺素诱导主动脉收缩后，可使有内皮的主动脉舒张，但对无内皮的主动脉无此作用。3. 人参皂苷诱导的舒张作用被3×10⁻⁷ M亚甲蓝（MB）和10⁻⁴ M NG-单甲基-L-精氨酸（L-NMMA）减弱，但不被10⁻⁵ M吲哚美辛抑制。4. 人参皂苷（10⁻⁴克/毫升，作用2分钟）增加有内皮环中cGMP的积累。L-NMMA和MB抑制人参皂苷诱导的cGMP积累。5. 这些数据表明，人参皂苷诱导的血管舒张是由内皮源性一氧化氮释放介导的，该释放增强了cGMP的积累。

Kim N D, Kang S Y, Schini V B

College of Pharmacy, Seoul National University, Korea.

Gen Pharmacol. 1994 Oct;25(6):1071-7. doi: 10.1016/0306-3623(94)90121-x.

Ginsenoside (10-100 mg/kg, i.v.) lowered blood pressure in a dose-dependent manner in rats. 2. Ginsenoside (10(-5)-3 x 10(-4) g/ml) relaxed the aorta after contractions were induced by 10(-6) M phenylephrine in the aorta with endothelium but not in that without endothelium. 3. The relaxation induced by ginsenoside was attenuated by 3 x 10(-7) M methylene blue (MB) and 10(-4) M NG-monomethyl-L-arginine (L-NMMA) but not inhibited by 10(-5) M indomethacin. 4. Ginsenoside (10(-4) g/ml for 2 min) increased the accumulation of cGMP in rings with endothelium. L-NMMA and MB inhibited the accumulation of cGMP induced by ginsenoside. 5. These data suggest that vascular relaxations induced by ginsenoside are mediated by release of endothelium-drived nitric oxide which enhances the accumulation of cGMP.

人参皂苷（10 - 100毫克/千克，静脉注射）以剂量依赖方式降低大鼠血压。2. 人参皂苷（10⁻⁵ - 3×10⁻⁴克/毫升）在由10⁻⁶ M去氧肾上腺素诱导主动脉收缩后，可使有内皮的主动脉舒张，但对无内皮的主动脉无此作用。3. 人参皂苷诱导的舒张作用被3×10⁻⁷ M亚甲蓝（MB）和10⁻⁴ M NG-单甲基-L-精氨酸（L-NMMA）减弱，但不被10⁻⁵ M吲哚美辛抑制。4. 人参皂苷（10⁻⁴克/毫升，作用2分钟）增加有内皮环中cGMP的积累。L-NMMA和MB抑制人参皂苷诱导的cGMP积累。5. 这些数据表明，人参皂苷诱导的血管舒张是由内皮源性一氧化氮释放介导的，该释放增强了cGMP的积累。