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Nuclear localization of the testis determining gene product SRY.睾丸决定基因产物SRY的核定位。
J Cell Biol. 1995 Mar;128(5):737-48. doi: 10.1083/jcb.128.5.737.
2
An SRY-related sequence on the marsupial X chromosome: implications for the evolution of the mammalian testis-determining gene.有袋类动物X染色体上一个与SRY相关的序列：对哺乳动物睾丸决定基因进化的启示。
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3
The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9].睾丸决定因子SRY（Y染色体性别决定区）和SOX9[SRY相关高迁移率族（HMG）盒9]的分子作用及调控
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Two independent nuclear localization signals are present in the DNA-binding high-mobility group domains of SRY and SOX9.在SRY和SOX9的DNA结合高迁移率族结构域中存在两个独立的核定位信号。
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Human sex reversal due to impaired nuclear localization of SRY. A clinical correlation.由于SRY核定位受损导致的人类性反转。临床相关性。
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From SRY to SOX9: mammalian testis differentiation.从SRY到SOX9：哺乳动物睾丸分化
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本文引用的文献

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HMGs everywhere.到处都是HMGs。
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Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.对培养的小鼠胚胎细胞生长及其发育成既定细胞系的定量研究。
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A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development.哺乳动物性别决定的调控级联假说：SRY抑制雄性发育的负调控因子。
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Anti-müllerian hormone: the Jost factor.抗苗勒管激素：约斯特因子。
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Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach.采用反向遗传学方法鉴定人类性别决定区Y（SRY）基因的转录单元、结构组织和启动子序列。
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Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.Sox-4是一种类似于Sry的HMG盒蛋白，是淋巴细胞中的一种转录激活因子。
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Evidence that the SRY protein is encoded by a single exon on the human Y chromosome.有证据表明，SRY蛋白由人类Y染色体上的一个外显子编码。
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睾丸决定基因产物SRY的核定位。

Nuclear localization of the testis determining gene product SRY.

作者信息

Poulat F, Girard F, Chevron M P, Gozé C, Rebillard X, Calas B, Lamb N, Berta P

机构信息

Centre de Recherche de Biochimie Macromoléculaire, CNRS/INSERM, Montpellier, France.

出版信息

J Cell Biol. 1995 Mar;128(5):737-48. doi: 10.1083/jcb.128.5.737.

DOI:10.1083/jcb.128.5.737
PMID:7876301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2120386/
Abstract

We have studied the expression of the human SRY protein (termed p27SRY) in two different cell lines by using specific antibodies. Confocal microscopy enabled us to localize p27SRY precisely in the nucleus in a discrete punctuate pattern. Furthermore, through microinjection experiments, we have demonstrated that the localization of the p27SRY protein into the nucleus was an event involving the NH2-terminal part of the high mobility group (HMG) domain. With the help of several synthetic peptides and various p27SRY mutants, we have characterized a bipartite basic motif in this part of the protein corresponding to a nuclear localization signal. This nuclear localization signal appears to be highly conserved in SRY box- and HMB box-containing proteins, suggesting common properties of nuclear targeting within the HMG box protein family.

摘要

我们通过使用特异性抗体，研究了人类SRY蛋白（称为p27SRY）在两种不同细胞系中的表达情况。共聚焦显微镜使我们能够将p27SRY精确地定位在细胞核中，呈离散的点状模式。此外，通过显微注射实验，我们证明了p27SRY蛋白进入细胞核是一个涉及高迁移率族（HMG）结构域NH2末端部分的事件。借助几种合成肽和各种p27SRY突变体，我们在该蛋白的这一部分鉴定出了一个双分型碱性基序，对应于一个核定位信号。这个核定位信号在含SRY盒和HMB盒的蛋白中似乎高度保守，表明HMG盒蛋白家族内核靶向具有共同特性。