Griess E A, Rensing S A, Grasser K D, Maier U G, Feix G
Institut für Biologie III, Freiburg, Federal Republic of Germany.
J Mol Evol. 1993 Aug;37(2):204-10. doi: 10.1007/BF02407357.
HMG boxes were initially identified as DNA-binding domains of the human RNA polymerase I (pol I) transcription factor hUBF and the animal high-mobility-group (HMG) protein family HMG1. Since then, numerous sequences of HMG-box-containing HMG proteins and other DNA-binding proteins from several species have become available. By sequence comparisons of a selected range of HMG boxes from these proteins and the construction of phylogenetic trees we show that the HMG box is highly conserved between DNA-binding proteins of organisms from all three eukaryotic kingdoms and that HMG boxes are linked by distinct evolutionary relationships. In addition, most HMG boxes display comparable hydropathy profiles and amino acid arrangements, which could serve as nuclear targeting sequences.
HMG框最初被鉴定为人RNA聚合酶I（pol I）转录因子hUBF和动物高迁移率族（HMG）蛋白家族HMG1的DNA结合结构域。从那时起，来自多个物种的含HMG框的HMG蛋白和其他DNA结合蛋白的众多序列已可得。通过对这些蛋白中选定范围的HMG框进行序列比较并构建系统发育树，我们表明HMG框在所有三个真核生物界的生物体的DNA结合蛋白之间高度保守，并且HMG框通过不同的进化关系相连。此外，大多数HMG框显示出可比的亲水性图谱和氨基酸排列，这可作为核靶向序列。
